Results 251 to 260 of about 4,955,430 (314)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The High Dispersion of Phenolic Concentration in the Seeds, Skins and Wines of <i>Vitis vinifera</i> L. Cultivars Limits Comparative Analysis and Varietal Categorization Under Heterogeneous Conditions. [PDF]

Antioxidants (Basel)
López-Solís R, Seguel-Rubio E, Muñoz-Pérez C, Vergara-López M, Belmar-Díaz R, Medel-Marabolí M, Aros-Orellana D, Laqui-Estaña J, Obreque-Slier E.   +8 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Genotype × Isolate Interactions for Tan Spot Resistance Screening in Mungbean. [PDF]

Plants (Basel)
Alamuru KC, Knight NL, Bottomley P, Ryan M, Kiss L, Martin A.   +5 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Partial root-zone drying enhances antioxidant signaling and physiological resilience in psyllium (<i>Plantago ovata</i>) under arid conditions. [PDF]

Plant Signal Behav
Iqbal R, Ahmad S, Suleiman K, Murtaza G, Ullah S, Harsonowati W, Jabborova D, Ahmad S, Ditta A, Yassin MT.   +9 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

From Wild-Growing Plants to Promising Candidates for Hemp Variety Development: Morphological and Phytochemical Characterization of Macedonian <i>Cannabis sativa</i> L. [PDF]

Molecules
Stoilkovska Gjorgievska V, Cvetkovikj Karanfilova I, Geskovski N, Trajkovska Matevska A, Davkova Stojanovski I, Todorov F, Karapandzova M, Stefkov G.   +7 more
europepmc   +1 more source

Polarized varieties, the fields of moduli and generalized Kummer varieties of abelian varieties

Proceedings of the Japan Academy, Series A, Mathematical Sciences, 1956
openaire   +3 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source