Results 81 to 90 of about 34,133 (225)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, Volume 16, Issue 6, Page 1102-1114, June 2026.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Investigation on nitrate induced histological alterations in vas deferens of rats

Journal of Trace Elements and Minerals
Background: Nitrate (NO3) contamination is a serious global concern as high level of NO3 adversely affect different components of the male reproductive system including accessory sex organs.
S.V. Rajini, R. Srushti, M. Sanchana, H.N. Sarjan   +3 more
doaj   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Identification of PDGFRα-positive interstitial cells in the distal segment of the murine vas deferens

Scientific Reports, 2021
Platelet-derived growth factor receptor-α (PDGFRα)-positive interstitial cells (ICs) are widely distributed in various organs and may be involved in the motility of various tubular organs.
Tasuku Hiroshige, Kei-Ichiro Uemura, Shingo Hirashima, Kiyosato Hino, Akinobu Togo, Keisuke Ohta, Tsukasa Igawa, Kei-Ichiro Nakamura   +7 more
doaj   +1 more source

Double labelling immunohistochemical characterization of autonomic sympathetic neurons innervating the sow retractor clitoridis muscle [PDF]

, 2008
Retrograde neuronal tracing and immunohistochemical methods were used to define the neurochemical content of sympathetic neurons projecting to the sow retractor clitoridis muscle (RCM). Differently from the other smooth muscles of genital organs, the RCM
Acone, Franca, Bo Minelli, Luisa, Botti, Maddalena, Gazza, Ferdinando, Palmieri, Giovanni, Panu, Rino, Ragionieri, Luisa   +6 more
core  

Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle [PDF]

, 2009
The term functionomics (Amin 2003, Neumann et al. 2004) refers to a postgenomic integrated Systems Biology (Attur et al. 2002) using a multidimensional approach for cells, tissues and organs.
Caricati-Neto, Afonso, Jurkiewicz, Aron, Jurkiewicz, Neide Hyppolito   +2 more
core   +3 more sources

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, Volume 183, Issue 12, Page 3195-3212, June 2026.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

Are evidence-based vasectomy surgical techniques performed in low-resource countries? [version 1; peer review: 2 approved]

Gates Open Research, 2019
Background:  Research evidence published 10 to 15 years ago has shown that the type of vasectomy surgical technique performed can influence the effectiveness and the safety of the procedure.  The objective of this study was to determine if evidence-based
Michel Labrecque
doaj   +1 more source

A new species of Paraberrapex Jensen, 2001 (Cestoda: Lecanicephalidea) from Squatina guggenheim Marini (Squatiniformes: Squatinidae) off Argentina [PDF]

, 2016
Paraberrapex atlanticus sp. n. (Cestoda, Lecanicephalidea) is described from the spiral intestine of the angel shark Squatina guggenheim Marini from coastal waters off Buenos Aires Province, Argentina. Paraberrapex atlanticus sp. n.
Ivanov, Veronica Adriana, Mutti, Leonardo Damián   +1 more
core   +1 more source

Update of the risk assessment on dioxins and dioxin‐like PCBs in feed and food

EFSA Journal, Volume 24, Issue 6, June 2026.
Abstract The European Commission asked EFSA to update its 2018 risk assessment on polychlorinated dibenzo‐p‐dioxins and dibenzofurans (PCDD/Fs) and dioxin‐like polychlorinated biphenyls (DL‐PCBs) in feed and food, based on the 2022 WHO Toxic Equivalency Factors (WHO2022‐TEFs).
EFSA Panel on Contaminants in the Food Chain (CONTAM Panel), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Jesús del Mazo, Andy Hart, Dieter Schrenk, José Cortiñas Abrahantes, Luisa Ramos Bordajandi, Francesca Riolo, Tuuli Tauriainen, Ron Hoogenboom   +27 more
wiley   +1 more source