Results 61 to 70 of about 3,764,275 (310)

Vascular Dementia [PDF]

Practical Neurology, 2003
Vascular dementia is one of the most frequently occurring dementia syndromes. Its prevalence is about 5% among subjects above 85 years of age. Elevated blood pressure and atherosclerosis are the most important risk factors. According to international criteria, vascular dementia usually occurs within three months after having a stroke.
F E, de Leeuw, J, van Gijn
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Case Report: Decoding genetic risks of vascular parkinsonism: a case series

Frontiers in Genetics
BackgroundVascular parkinsonism (VaP) is a subtype of parkinsonism which needs better characterization of its risks and determinants.ObjectiveThe aim of this report is to present an understanding of genetic risks of vascular parkinsonism.MethodsFive ...
Ali Shalash, Salma El-Shafie, Peter George, Tamer Roushdy, Mai Fathy, Mohamed H. Yousef, Mahmoud El-Belkimy, Mohamed Ossama Abdulghani, Mohamed Salama   +8 more
doaj   +1 more source

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

eLife, 2021
The formation of new blood vessel networks occurs via angiogenesis during development, tissue repair, and disease. Angiogenesis is regulated by intracellular endothelial signalling pathways, induced downstream of vascular endothelial growth factors ...
Kazuhide S Okuda, Mikaela S Keyser, David B Gurevich, Caterina Sturtzel, Elizabeth A Mason, Scott Paterson, Huijun Chen, Mark Scott, Nicholas D Condon, Paul Martin, Martin Distel, Benjamin M Hogan   +11 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The Role of Vascular-Immune Interactions in Modulating Chemotherapy Induced Neuropathic Pain

Frontiers in Pharmacology, 2022
Chemotherapy causes sensory disturbances in cancer patients that results in neuropathies and pain. As cancer survivorships has dramatically increased over the past 10 years, pain management of these patients is becoming clinically more important. Current
Tameille Valentine, Lydia Hardowar, Jasmine Elphick-Ross, Richard P. Hulse, Mark Paul-Clark   +4 more
doaj   +1 more source

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

High throughput RNAi assay optimization using adherent cell cytometry

Journal of Translational Medicine, 2011
Background siRNA technology is a promising tool for gene therapy of vascular disease. Due to the multitude of reagents and cell types, RNAi experiment optimization can be time-consuming.
Pradhan Leena, Chun Maggie, Nabzdyk Christoph S, LoGerfo Frank W   +3 more
doaj   +1 more source

Supplemental macronutrients and microbial fermentation products improve the uptake and transport of foliar applied zinc in sunflower (Helianthus annuus L.) plants. Studies utilizing micro X-ray florescence. [PDF]

, 2014
Enhancing nutrient uptake and the subsequent elemental transport from the sites of application to sites of utilization is of great importance to the science and practical field application of foliar fertilizers.
Cliff eRamsier, Dandi eHou, Judith eJernstedt, Lingli eLu, Minzhe eZhang, Patrick eBrown, Ruohan eXie, Ruohan eXie, Shengke eTian, Shengke eTian   +9 more
core   +2 more sources