Results 101 to 110 of about 14,212,615 (258)

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Developing Appropriateness Criteria for Pediatric Vascular Access

, 2020
OBJECTIVES: To describe the methodology undertaken to provide guidance on the appropriateness, as well as inappropriateness, of vascular access device selection, characteristics, and insertion technique for pediatric patients.
Ullman, AJ, Cooke, M, Chopra, V, Brown, E, Kleidon, T, Bernstein, SJ, Rickard, CM   +6 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Spanish Clinical Guidelines on Vascular Access for Haemodialysis

, 2018
El acceso vascular para hemodiálisis es esencial para el enfermo renal tanto por su moribimortalidad asociada como por su repercusión en la calidad de vida.
Merino, Jose Luis, Fontsere, Nestor, Caro, Pilar, Hernan, David, Valdes, Pablo, Gruss, Enrique, Gimenez-Gaibar, Antonio, Moreno, Teresa, Del-Pozo, Jose Luis, Moñux, Guillermo, Arenas, Maria Dolores, Martinez, Maria Teresa, de la Fuente, Natalia, Barba, Angel, Garcia-Revillo, Jose, Ramirez-de-Arellano, Manel, Vallespin, Joaquin, Ibeas, Jose, Arribas, Patricia, Sanchez-de-la-Nieta, Maria Dolores, Roca-Tey, Ramon, Fernandez-Lucas, Milagros, Fernandez-Quesada, Fidel, Marti-Monros, Anna, Lopez-Espada, Cristina   +24 more
core   +1 more source

Vascular Access

Turkish Journal of Nephrology, 2019
Hemodialysis patients are connected to life by means of vascular access. The complications of vascular access represent one of the most important causes of morbidity, mortality and high healthcare costs in the hemodialysis patients.
Berna YELKEN, Mehmet Şükrü SEVER
doaj  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Risk Factors and Development of a Risk Prediction Model for PICC-Related Thrombosis in Radiotherapy Inpatients: A Single-Center Retrospective Cohort Study

Risk Management and Healthcare Policy
Qin-Mei Lin,1,* Qin-Lin Guo,2,* Zhuang-Bin Lin,3 Ai-Ying Chen,1 Zhen Chen,4 Qiu-Yan Zhang,2 Li-Yuan Chen,4 Bi-Hua Lin1 1Department of Outpatient Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, People’s Republic ...
Lin QM, Guo QL, Lin ZB, Chen AY, Chen Z, Zhang QY, Chen LY, Lin BH   +7 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source