Results 181 to 190 of about 73,988 (260)

En face localization of retinal telangiectatic capillaries using OCT compared with ICG angiography in chronic vascular macular oedema

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Retinal telangiectatic capillaries (TelCaps) are microvascular abnormalities associated with chronic vascular macular oedema and suboptimal response to intravitreal therapy. Targeted laser photocoagulation is beneficial but requires precise localization using indocyanine green angiography (ICG‐A), the reference standard. However, ICG‐A
Lucas Unger   +7 more
wiley   +1 more source

Pearls and Pitfalls in the Management of Vascular Anomalies. [PDF]

open access: yesSemin Intervent Radiol
Sanon O, Henderson A, Rosen RJ.
europepmc   +1 more source

Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population‐Based Study From Southern Finland

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Childhood ischemic stroke is rare but causes substantial long‐term morbidity, and its heterogeneous aetiology complicates timely diagnosis and management. Methods We conducted a retrospective population‐based observational study using hospital data and chart review to describe diagnostics, treatment and outcomes of ischemic stroke in ...
Jussi V. Leinonen   +8 more
wiley   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

open access: yesBrain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich   +5 more
wiley   +1 more source

A new approach to the treatment of microcystic lymphatic malformations in children

open access: yesAsian Journal of Surgery
Dan Song, Jing Li, Liang Wang, Lei Guo
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Vascular Anomalies of the Head and Neck - Case Series. [PDF]

open access: yesIndian J Otolaryngol Head Neck Surg
Soumya MS, Sreenivas V, Thomas TT.
europepmc   +1 more source

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