Results 71 to 80 of about 77,717 (297)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery

Advanced Science, EarlyView.
A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi‐Tao Yang, Yong Fan, Xiaodong Zhu   +5 more
wiley   +1 more source

CME- Vascular anomalies

, 2005
Management of vascular anomalies is an emerging multidisciplinary, super-specialisation field involving several surgical, medical and radiological specialties.
Jyotsna Murthy
core   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Severe adverse events during sirolimus "off-label" therapy for vascular anomalies.

, 2021
OBJECTIVES Clinical studies have shown low toxicity and a favorable safety profile for sirolimus in vascular anomalies. Here, we describe severe adverse events (SAEs) observed during "off-label use" for vascular anomalies. METHODS We performed a
Davila, Victoria, Hanke, Christof, Jochen Rössler, Mestre, Sandrine, El Hachem, Maya, Baselga, Eulalia, Iris Baumgartner, Friedrich G. Kapp, Hanke, Christof Andreas, Loichinger, Wolfgang, Dario Haeberli, Kapp, Friedrich, Diociaiuti, Andrea, Eulalia Baselga, Sandrine Mestre, Celis, Veronica, Baumgartner, Iris, Kapp, Friedrich G., Andrea Diociaiuti, Kapp, Friedrich G, Niemeyer, Charlotte, Niemeyer, Charlotte M., Isabelle Quéré, Charlotte M. Niemeyer, Quéré, Isabelle, Christof Hanke, Wolfgang Loichinger, Prokop, Aram, Haeberli, Dario, Rössler, Jochen, Maya El Hachem, Aram Prokop, Veronica Celis, Niemeyer, Charlotte M, Victoria Davila   +34 more
core   +1 more source

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Association of miR-938 rs2505901 T > C polymorphism with reduced risk of venous malformations in a Chinese population

Scientific Reports
Venous malformations are a common congenital vascular disorder. MicroRNAs are micro non-coding RNAs that are responsible for regulating the expression of genes after transcription.
Shifeng Xie, Qiuyi Chen, Xi Lin, Guitao Wu, Xiaoyun Tan, Zhenyin Liu   +5 more
doaj   +1 more source

Multimodal management of late-stage Bockenheimer disease complicated by severe anemia and coagulopathy: a case report

Frontiers in Medicine
BackgroundBockenheimer disease is a rare subtype of venous malformations that involves all tissue planes of an upper extremity. This condition progresses throughout life and may cause pain, swelling, hematologic complications, and loss of function ...
Zilu Wang, Mingzhe Wen, Qianyun Han, Deming Wang, Lixin Su, Xindong Fan   +5 more
doaj   +1 more source

Facial Vascular Anomalies Coexist With Intracranial Venous And Cavernous Angioma: A Case Report

, 2007
Soft-tissue vascular anomalies consist of hemangiomas and vascular malformations. Vascular mal-formations are subclassified according to the predominant channel type, namely, arterial, venous, capillary, lymphatic, or a combination of these. Intracranial
İlhan Erden, Banu Yağmurlu, Pınar Koşar, Hasan Yiğit, Nuray Yiğit   +4 more
core  

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source