Results 101 to 110 of about 2,444,251 (292)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature [PDF]
, 2010 Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet vascularized retinal astrocytes, but also by retinal ...
Michael B. Powner +43 more
core +3 more sources
Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function
JCI InsightThe expression and functional relevance of the gap junction molecule connexin-45 (Cx45; GJC1) in lymphatic endothelium were not previously known. We found that Cx45 was expressed widely in the endothelium of murine lymphatics, in both valve and nonvalve ...
Michael J. Davis +6 more
doaj +1 more source
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1
JCI Insight, 2023 Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain ...
Claire A. Ruddiman +12 more
doaj +1 more source
The American Journal of Cardiology, 2001 Cardiovascular disease has been the leading cause of death for men and women in this country since 1921 and is currently the leading cause of death in the world. Adding to the sense of urgency about disease prevention is the recent finding that the initial lesions of atherosclerotic vascular disease may begin within the first year of life-or even ...
Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA ( host institution ) +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
, 2021 Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether ...
de Angelis, Celio D. +5 more
core +1 more source
The Journal of Clinical InvestigationEndothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, and this supports an antiinflammatory phenotype. High laminar shear stress also induces flow-aligned cell elongation and front-rear polarity, but whether these are ...
Soon-Gook Hong +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
JCI InsightCantú syndrome is a multisystem disorder caused by gain-of-function (GOF) mutations in KCNJ8 and ABCC9, the genes encoding the pore-forming inward rectifier Kir6.1 and regulatory sulfonylurea receptor SUR2B subunits, respectively, of vascular ATP ...
Elsayed Metwally +10 more
doaj +1 more source