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Microphysiological Systems of Lymphatics and Immune Organs
Advanced Healthcare Materials, EarlyView.This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain +2 more
wiley +1 more source
Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling
Advanced Healthcare Materials, EarlyView.A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl +8 more
wiley +1 more source
Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions
Advanced Healthcare Materials, EarlyView.Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Commercial vascular grafts are made from ePTFE, a highly hydrophobic, foreign material that fails at a high rate in small‐diameter applications. Plasma polymer nanoparticles (PPN) are a versatile material functionalisation tool, used here to present fibrillin‐1 fragment PF8 on the graft surface.
Bob S. L. Lee +9 more
wiley +1 more source
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2021
The complex development of the brain vascular system can be broken down by embryonic stages and anatomic locations, which are tightly regulated by different factors and pathways in time and spatially. The adult brain is relatively quiescent in angiogenesis.
Yao, Yao, Sonali S, Shaligram, Hua, Su
openaire +2 more sources
The complex development of the brain vascular system can be broken down by embryonic stages and anatomic locations, which are tightly regulated by different factors and pathways in time and spatially. The adult brain is relatively quiescent in angiogenesis.
Yao, Yao, Sonali S, Shaligram, Hua, Su
openaire +2 more sources
2013
Vascular biology is the study of the physiology of the vasculature and how it may be the target for disease processes. An understanding of vascular biology is central to the study of rheumatic disease for three reasons: it is an integral part of a functioning immune system; it is the primary site of pathology in many conditions; and it is the site of ...
Clare Thornton, Justin Mason
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Vascular biology is the study of the physiology of the vasculature and how it may be the target for disease processes. An understanding of vascular biology is central to the study of rheumatic disease for three reasons: it is an integral part of a functioning immune system; it is the primary site of pathology in many conditions; and it is the site of ...
Clare Thornton, Justin Mason
openaire +2 more sources
Sphingolipids In Vascular Biology
2002A significant body of evidence now exists to indicate that certain sphingolipids such as the sphingomyelin metabolites, ceramide, sphingosine and sphingosine-1-phosphate (S-1-P) are potent modulators of cell behavior’2. This article reviews recent findings pertaining to the biological activities of two sphingolipids, ceramide and S-1-P.
Kelley M, Argraves +2 more
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Vascular biology and vasculitis
APMIS, 2009The inflammation of blood vessel walls that is associated with autoimmune disorders characterized by anti‐neutrophil cytoplasm antibodies (ANCA) represents dysregulation of normal physiological processes, whereby neutrophils recruited to the vessel wall by cytokine‐activated endothelium show destructive behaviours that initiate damage with endothelial ...
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Vascular developmental biology: getting nervous
Current Opinion in Genetics & Development, 2000First described in the developing nervous system, Semaphorin III/Neuropilin, Ephrin/Eph, and Delta/Notch signaling relays have now been implicated in the elaboration of the blood vessel network during embryogenesis.
D T, Shima, C, Mailhos
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