Results 101 to 110 of about 274,400 (353)
Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans [PDF]
, 2019 Although the association between high blood pressure (BP), particularly in midlife, and late-life dementia is known, less is known about variations by race and sex.
Cushman, Mary +9 more
core +1 more source
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, EarlyView.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source
Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder? [PDF]
, 2013 Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship.
Kelleher, Rory J., Soiza, Roy L
core +1 more source
Advanced Science, EarlyView.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia
Neural Regeneration ResearchWith an increase in global aging, the number of people affected by cerebrovascular diseases is also increasing, and the incidence of vascular dementia—closely related to cerebrovascular risk—is increasing at an epidemic rate.
Xiaorong Zhang +5 more
doaj +1 more source
Clinical efficacy of long-term treatment in patients with vascular dementia
Бюллетень сибирской медицины, 2011 To study efficacy and safety of prolonged course of cerebrolysin therapy in vascular dementia, 48 patients, aged from 59—77 years, with mild and moderate dementia have been studied.
I. A. Suvorova
doaj +1 more source
Advanced Science, EarlyView.A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu +8 more
wiley +1 more source
Dementia due to cerebral small vessel damage: Current ideas on its pathogenesis and therapy
Неврология, нейропсихиатрия, психосоматика, 2014 Ever-increasing attention now focusses on dementia caused by small vessel damage when considering cerebrovascular disease leading to cognitive impairments (CIs).
I. V. Damulin, E. V. Ekusheva
doaj +1 more source
Predicting Alzheimer's risk: why and how? [PDF]
, 2011 Because the pathologic processes that underlie Alzheimer's disease (AD) appear to start 10 to 20 years before symptoms develop, there is currently intense interest in developing techniques to accurately predict which individuals are most likely to become
Barnes, Deborah E, Lee, Sei J
core +2 more sources
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source