Results 201 to 210 of about 274,400 (353)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization. [PDF]

Nat Aging
Taylor-Bateman V, Bothongo P, Walker V, Kehoe PG, Nordestgaard LT, Ben-Shlomo Y, Davies NM, Williams DM, Anderson EL.   +8 more
europepmc   +1 more source

Additional files 1: of Blood pressure at age 60â 65 versus age 70â 75 and vascular dementia: a population based observational study

, 2017
Mingkai Peng, GuanMin Chen, Karen Tang, Hude Quan, Eric Smith, Peter Faris, Vladimir Hachinski, Norm Campbell   +7 more
openalex   +1 more source

CSF Biomarkers Profile in CADASIL—A Model of Pure Vascular Dementia: Usefulness in Differential Diagnosis in the Dementia Disorder [PDF]

, 2010
Patrizia Formichi, Lucilla Parnetti, Elena Radi, Gabriele Cevenini, Maria Teresa Dotti, Antonio Federico   +5 more
openalex   +1 more source

Imaging Venous Transit Time and Blood–Brain Barrier Permeability of the Deep Brain

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Imaging of venous vessels with advanced pulse sequences allows the assessment of important hemodynamic parameters. Previous work has measured venous transit time (VTT) and blood–brain barrier (BBB) water permeability in cortical tissue.
Wen Shi, Jie Song, Jiani Wu, Yifan Gou, Zhiyi Hu, Vivek Yedavalli, Zixuan Lin, Hanzhang Lu   +7 more
wiley   +1 more source

Vascular dementia: World Stroke Organization fact sheet 2026. [PDF]

Int J Stroke
Cai Y, Mok VCT, Markus HS.
europepmc   +1 more source

Perspectives on ethnic and racial disparities in Alzheimer\u27s disease and related dementias: Update and areas of immediate need [PDF]

, 2019
Babulal, Ganesh M, et al,, Roe, Catherine M   +2 more
core   +1 more source

Ultrafast fMRI Detects Age‐Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Aging impacts pulsatility of blood vessels in the brain, reflecting vascular health. Resolving characteristics of cardiac pulsatility requires faster acquisitions than traditional fMRI. An ultrafast fMRI method was developed and applied to sample several harmonics of cardiac pulsations at 7 T.
Charles Marchini, Dema Abdelkarim, Yuhui Chai, Monica Fabiani, Gabriele Gratton, Bradley P. Sutton   +5 more
wiley   +1 more source

Edaravone dexborneol attenuates cognitive impairment in a rat model of vascular dementia by inhibiting hippocampal oxidative stress and inflammatory responses and modulating the NMDA receptor signaling pathway

Hui Guo, Haodong Li, Zhisheng Jia, Shuyu Ma, Jin Zhang   +4 more
openalex   +1 more source

Comparison of visual evoked potential changes in patients with alzheimer, vascular dementia and minimal cognitive Impairment with healthy people: a case-control study

, 2020
Narges Khodaparast, Nazila Malekian, Zahra Vahabi, Davood Fathi, Shahram Oveisgharan, Farzad Fatehi, Siamak Abdi   +6 more
openalex   +1 more source