Results 251 to 260 of about 274,400 (353)

Temporal comorbidity patterns in Alzheimer's disease and vascular dementia: A population-based observational study in UK Biobank. [PDF]

Alzheimers Dement (Amst)
Walsh C, Fogel A, Schalkamp AK, Mabiala V, Shariati B, Sandor C, Ryten M, Nilforooshan R, Barnaghi P.   +8 more
europepmc   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Vascular dementia: novel insights through multiscale mechanistic modeling. [PDF]

Signal Transduct Target Ther
Ye Q, Won S, Cai D.
europepmc   +1 more source

Subclinical vascular risk composites and dementia imaging biomarkers 17–20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA)

Marc D. Rudolph, Jordan E. Tanley, Jingzhong Ding, Kiran Kumar Solingapuram Sai, Haiying Chen, Kathleen M. Hayden, Yongmei Liu, R. Nick Bryan, Ilya M. Nasrallah, Sudipto Dolui, Mohamad Habes, José A. Luchsinger, Robert A. Koeppe, Susan R. Heckbert, Suzanne Craft, Samuel N. Lockhart, Timothy M. Hughes   +16 more
openalex   +1 more source

Vascular dementia in the elderly

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2017
openaire   +3 more sources

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway. [PDF]

Front Aging Neurosci
Huang X, Liu J, Ren Y, Liu D, Cai J, Cao L, Lei T, Wu Y.   +7 more
europepmc   +1 more source