Results 61 to 70 of about 274,400 (353)

Macrophages come to mind as keys to cognitive decline [PDF]

, 2016
Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison, Davies, Faraco, Launer, Liu, Tomasz J. Guzik   +5 more
core   +1 more source

Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?—A Pilot Study [PDF]

, 2020
Path integration spatial navigation processes are emerging as promising cognitive markers for prodromal and clinical Alzheimer’s disease (AD). However, such path integration changes have been less explored in Vascular Cognitive Impairment (VCI), despite ...
Coughlan, Gillian, Hornberger, Michael, Jeffs, Stephen, Lowry, Ellen, Puthusseryppady, Vaisakh   +4 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway

Journal of Pharmacological Sciences, 2019
Recent studies suggested that Chotosan has ameliorative effects on vascular dementia through antioxidative pathways. Nevertheless, no systematic pharmacological research was conducted to evaluate the contribution of nuclear factor-E2-related factor 2 ...
Pan Jiang, Lei Chen, Jing Sun, Jingsong Li, Jian Xu, Wenyuan Liu, Feng Feng, Wei Qu   +7 more
doaj   +1 more source

Update on diverse vascular cognitive impairment (VCID)

Veins and Lymphatics, 2022
Background. As the US population becomes increasingly older and more diverse, the number of Americans with dementia is expected to rise substantially, particularly the number of those with concomitant vascular disease.
Charles DeCarli
doaj   +1 more source

Big data and data repurposing – using existing data to answer new questions in vascular dementia research [PDF]

, 2017
Introduction: Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost efficient hypothesis generating ...
A Abdul-Rahim, AH Noel-Storr, Andreas Charidimou, Charlotte J. Roberts, CN Martyn, Craig W. Ritchie, CW Ritchie, D Jang, D Kerr, D Religa, DA Levine, Deborah A. Levine, Fergus N. Doubal, G Mead, G Perera, G Perera, G Rands, G. David Batty, GE Mead, Gillian Mead, HA Mucke, Hermann A. M. Mucke, HL Dunn, I Chalmers, J Danesh, J Mindell, J Sultana, JPA Ioannidis, L Gray, M Ali, M Brainin, M Jokela, M Porter, M Porter, Maria Eriksdotter, Martin Hofmann-Apitius, Myzoon Ali, NL Catlett, P Langhorne, R Lees, R Patel, R Stewart, R Xu, Robert Stewart, S Garcia-Ptacek, SK McCann, T Hoffman, T Skillbäck, TC Russ, TC Russ, TC Russ, TC Russ, Terence J. Quinn, TJ Quinn, Tom C. Russ, William Whiteley, Yun-Hee Kim   +56 more
core   +8 more sources

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger onset age of CHD is associated with a higher risk of incident dementia.
Jie Liang, Chenglong Li, Darui Gao, Qian Ma, Yongqian Wang, Yang Pan, Wenya Zhang, Wuxiang Xie, Fanfan Zheng   +8 more
doaj   +1 more source

Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure [PDF]

, 2015
ACKNOWLEDGMENTS This study was funded by Alzheimer’s Research UK (ARUK) and the Aberdeen Biomedical Imaging Centre, University of Aberdeen. GDW, ADM and CS are part of the SINASPE collaboration (Scottish Imaging Network - A Platform for Scientific ...
Ahearn, Trevor S., Cameron, George G., Murray, Alison D., Schwarzbauer, Christian, Waiter, Gordon D.   +4 more
core   +1 more source

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source