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Hypercoagulability and Vascular Disease

Hematology/Oncology Clinics of North America, 2018
The presence of a high incidence of thrombotic events, mainly in nontransfusion-dependent β-thalassemia syndromes, has led to the identification of a hypercoagulable state in thalassemia patients. This article highlights the mechanisms leading to hypercoagulability in thalassemia.
Taher, Ali T.   +4 more
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Hypertension and Vascular Disease

Journal of Cardiovascular Pharmacology, 1991
The use of antihypertensive drug treatment has altered the natural history of hypertension. Whereas congestive heart failure, cerebral hemorrhage, and renal failure were the major complications of untreated severe hypertension, myocardial infarction and thrombotic stroke have emerged as major problems in treated hypertensive patients. None of the major
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COLLAGEN VASCULAR DISEASES

Medical Clinics of North America, 1998
Collagen vascular diseases are multisystem disorders that frequently affect the skin. At times, cutaneous disease is the initial manifestation. This article focuses on lupus erythematosus, dermatomyositis, and sclerodermoid syndromes.
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Mechanisms of Vascular Disease

2016
Scleroderma (systemic sclerosis (SSc)) is to a large degree identified by the vascular features which may precede the onset of fibrosis by months or even years. Abnormalities in microvessel morphology and vascular dysfunction occur early and evolve into a distinctive vasculopathy that relentlessly advances in nearly all affected organs.
MANETTI, MIRKO, Kahaleh, Bashar
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Are MPNs Vascular Diseases?

Current Hematologic Malignancy Reports, 2013
A high risk of arterial and venous thrombosis is the hallmark of chronic myeloproliferative neoplasms (MPNs), particularly polycythemia vera (PV) and essential thrombocythemia (ET). Clinical aspects, pathogenesis and management of thrombosis in MPN resemble those of other paradigmatic vascular diseases.
Finazzi, G   +2 more
openaire   +3 more sources

Retinal Vascular Diseases

Occupational Health Nursing, 1983
The eye can be affected by obstructive phenomena within large vessels, such as the corotid arteries, as well as in the ophthalmic artery, central retinal artery, and branch retinal arteries. The visual impairment seen with central retinal vein obstruction usually occurs over a period of days to weeks, and although vision improves spontaneously in some ...
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Vascular Disease of the Spine

The Neurologist, 2015
Vascular insults to the spinal cord are substantially less common than their corresponding events in the brain; it has been estimated, for example, that spinal cord infarcts make up ≤ 1% of ischemic events in the central nervous system. Although the public health burden of spinal cord injury remains severe, the majority of this burden stems from ...
David J. Hart, Charles Munyon
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Rho and vascular disease

Atherosclerosis, 2005
The Rho family GTPases are regulatory molecules that link surface receptors to organisation of the actin cytoskeleton and play major roles in fundamental cellular processes. In the vasculature Rho signalling pathways are intimately involved in the regulation of endothelial barrier function, inflammation and transendothelial leukocyte migration ...
Rolfe, B. E.   +4 more
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Vascular diseases of the spine

2016
Spinal vascular diseases are rare but potentially devastating diseases affecting the cord. This chapter gives an overview about their imaging features, differential diagnoses, the neurologic symptomatology, and the potential therapeutic approaches of these diseases, which might vary depending on the underlying pathologic condition.
Timo Krings, Guillaume Saliou
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Prostacyclin and vascular disease

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1981
We hypothesize that prostacyclin (PGI 2 ) is an anti-atherosclerotic hormone and that atherosclerosis develops when endothelial PGI 2 synthetase is inhibited by lipid peroxides. Serum lipid peroxides occur in low-density lipoproteins (LDL).
A. Szczeklik   +3 more
openaire   +3 more sources

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