Results 51 to 60 of about 4,094,904 (310)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

MicroRNAs in Vascular Eye Diseases

, 2020
Since the discovery of the first microRNA (miRNA) decades ago, studies of miRNA biology have expanded in many biomedical research fields, including eye research.
Jing Chen, Chi-Hsiu Liu, William R. Britton, Shuo Huang   +3 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Anticoagulant management in an antithrombin-deficient pregnant woman with a history of venous thromboembolism: a case report

Thrombosis Journal
Background Antithrombin deficiency (ATD) in pregnant patients significantly increases the risk of venous thromboembolism (VTE), but guidelines for managing anticoagulation during pregnancy, labour, and postpartum in patients with ATD are limited.
Matija Kozak, Tjaša Vižintin Cuderman, Mojca Božič Mijovski, Miha Lučovnik, Marko Miklič, Gregor Tratar, Tamara Rojnik   +6 more
doaj   +1 more source

Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling

Nature Communications, 2018
Lymphotoxin beta receptor (LTβR) signalling regulates leukocyte migration through the lymphatic endothelial layers. Here, the authors show that treatment of an LTβR-derived decoy peptide can target the non-classical NFκB pathway to inhibit T cell and ...
Wenji Piao, Yanbao Xiong, Konrad Famulski, C. Colin Brinkman, Lushen Li, Nicholas Toney, Chelsea Wagner, Vikas Saxena, Thomas Simon, Jonathan S. Bromberg   +9 more
doaj   +1 more source

Vascular Permeability in Diseases

International Journal of Molecular Sciences, 2022
Vascular permeability is a selective mechanism that maintains the exchange between vessels, tissues, and organs. The regulation was mostly studied during the nineteenth century by physiologists who defined physical laws and equations, taking blood, tissue interstitial, and oncotic pressure into account.
Jean-Luc Wautier, Marie-Paule Wautier
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Efficacy and safety of mechanical pulmonary valve replacement: a comprehensive systematic review and meta-analysis

Journal of Cardiothoracic Surgery
Background Pulmonary valve replacement (PVR) is the most common valve replacement procedure for pulmonary valve dysfunction in congenital heart diseases (CHD).
Ali Rafati, Sina Rashedi, Yeganeh Pasebani, Milad Vahedinejad, Hamed Ghoshouni, Yaser Toloueitabar, Mostafa Mousavizadeh, Sedigheh Saedi, Amirhosein Jalali, Zahra Khajali, Hassan Tatari, Fahimeh Farrokhzadeh, Hooman Bakhshandeh, Maziar Gholampour Dehaki, Behshid Ghadrdoost, Parham Sadeghipour   +15 more
doaj   +1 more source

Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus

Cardiovascular Diabetology, 2018
Background Deteriorated arterial function and high incidence of cardiovascular events characterise diabetes mellitus. Metformin and recent antidiabetic drugs, SGLT2 inhibitors, reduce cardiovascular events.
Mojca Lunder, Miodrag Janić, Miha Japelj, Andrej Juretič, Andrej Janež, Mišo Šabovič   +5 more
doaj   +1 more source

Self-Radiopaque Markers Guiding Physician-Modified Fenestration (S-Fenestration) in Aortic Arch Endovascular Repair

Frontiers in Cardiovascular Medicine, 2021
Backgrounds and Objectives: Thoracic endovascular aortic repair (TEVAR) has currently become the “first-line choice” for descending aortic pathologies. For pathologies located at the aortic arch, TEVAR with physician-modified fenestration (PMF) has been ...
Xin Li, Xin Li, Chang Shu, Chang Shu, Chang Shu, Quanming Li, Quanming Li, Hao He, Hao He, Ming Li, Ming Li, Lunchang Wang, Lunchang Wang, Jiehua Li, Jiehua Li, Dingxiao Liu, Dingxiao Liu, Mingyuan Du, Mingyuan Du   +18 more
doaj   +1 more source