Results 311 to 320 of about 357,387 (353)
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Vascular Endothelial Growth Factor (VEGF) Inhibition - A Critical Review
Anti-Cancer Agents in Medicinal Chemistry, 2007Angiogenesis, or formation of new blood capillaries from preexisting vessels, plays both beneficial and damaging roles in the organism. It is a result of a complex balance of positive and negative regulators, and vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic factors involved in tumor angiogenesis.
Irina Sousa, Moreira +2 more
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Vascular endothelial growth factors (VEGF): role in pathological processes
Vestnik oftal'mologii, 2016Russian and foreign literature sources on vascular endothelial growth factors (VEGF) from different parts of the human body, their prevalence and involvement in pathological processes were analyzed. A conclusion has been drawn that further research on different types of VEGF is needed.
Yu A, Borzilova +2 more
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Vascular Endothelial Growth Factor (VEGF)
2016One of the best-validated signalling pathways in angiogenesis is vascular endothelial growth factor (VEGF) and its receptors. VEGF family encompasses 7 VEGF glycoproteins members including, VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E and placental growth factors 1 and 2 (PLGF). Of these, the very well-characterized member is VEGF-A. Vascular endothelial
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Vascular Endothelial Growth Factor (VEGF) Receptors
1995Abstract Two tyrosine kinases have been recently identified as putative VEGF receptors (deVries et al. 1992; Terman et al. 1992a). The flt-1 (fms-like-tyrosine kinase; Shibuya et al. 1990) and KOR (kinase domain region; Terman et al. 1991) proteins have been shown to bind VEGF with high affinity.
J E Park, N Ferrara
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Vascular Endothelial Growth Factor (VEGF) Inhibition by Small Molecules
Journal of Chemotherapy, 2004Angiogenesis is essential for primary tumours to grow and metastasise, and is driven by the production of positive angiogenic factors. The Vascular Endothelial Growth Factor (VEGF) family is central to the process of angiogenesis and comprises 5 molecules designated A, B, C, D and E. VEGF is overexpressed in several solid malignancies.
S I, Ahmed, A L, Thomas, W P, Steward
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Le VEGF (vascular endothelial growth factor)
Sang thrombose vaisseaux, 2009Auteur(s) : Yasmine Zouggari Inserm 970, PARCC, 56 Rue Leblanc 75015, Paris Les vaisseaux sanguins assurent le transport d’oxygene et de nutriments vers l’ensemble des organes et des tissus. La formation de neo-vaisseaux (ou angiogenese) s’observe dans des conditions physiologiques, lors du developpement embryonnaire et de la croissance.
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The biology of vascular endothelial growth factor-B (VEGF-B)
Pulmonary Pharmacology & Therapeutics, 2006The formation of new blood vessels (angiogenesis) is critical for both embryonic development and a variety of normal postnatal physiological processes. Various pathological processes, most notably tumour growth and chronic inflammation, are also known to be dependent on the new vessel formation.
Andrew D, Nash +3 more
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On the detection of neutrophil-derived vascular endothelial growth factor (VEGF)
Journal of Immunological Methods, 1999In recent years, several investigators have addressed the question of whether mature polymorphonuclear neutrophils (PMN) are able to secrete cytokines. Their studies have brought forward new and exciting discoveries, by establishing that the release of inflammatory cytokines constitutes a novel and important aspect of the neutrophil biology, thereby ...
SCAPINI, Patrizia +2 more
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Vascular Endothelial Growth Factor (VEGF) in Astrocytic Gliomas – A Prognostic Factor?
Journal of Neuro-Oncology, 1999Survival in astrocytic gliomas is closely related to WHO tumor grade. Within one tumor grade, especially in grade II and III tumors, the clinical course is variable and can hardly be predicted by histological criteria. Neovascularization is a neuropathological hallmark in high grade gliomas and angiogenic factors may play an important role in malignant
R D, Oehring +6 more
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Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas
Medical and Pediatric Oncology, 2000Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen that stimulates angiogenesis and plays a crucial role in tumor growth. The aim of the present study was to evaluate the expression of VEGF and of its two high-affinity tyrosine kinase receptors (KDR and Flt-1) in neuroblastoma surgical samples and cell lines.The VEGF, KDR,
Langer, Ingrid +5 more
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