Results 181 to 190 of about 129,720 (304)

Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts. [PDF]

Biomater Res
Lu P, Wang T, Liao S, He Z, Cheng S, Wang T, Cheng Z, An Y, Zhou S, Wang M, Zhang Q, Shu C.   +11 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

A computational framework to optimize the mechanical behavior of synthetic vascular grafts. [PDF]

J Mech Behav Biomed Mater
Jiang D, Robinson AJ, Nkansah A, Leung J, Guo L, Maas SA, Weiss JA, Cosgriff-Hernandez EM, Timmins LH.   +8 more
europepmc   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Endothelial TRIM35-Regulated MMP10 Release Exacerbates Calcification of Vascular Grafts. [PDF]

Adv Sci (Weinh)
Leng Y, Wang W, Lu J, Chen J, Chen X, Li Y, Wang J, Liu Y, Tan Q, Yang W, Jiang Y, Huang P, Cai J, Yuan H, Weng L, Xu Q, Lu Y.   +16 more
europepmc   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Immune-mediated regeneration of cell-free vascular grafts in an ovine model. [PDF]

NPJ Regen Med
Nasiri B, Das A, Ramachandran K, Bhamidipati SH, Wu Y, Venkatesan S, Gunawan R, Swartz DD, Andreadis ST.   +8 more
europepmc   +1 more source

Human intestinal and multivisceral transplantation [PDF]

, 1994
Abu-Elmagd, K, Cillo, U, Fung, JJ, Furukawa, H, Marino, IR, Scotti-Foglieni, CL, Starzl, TE, Todo, S, Tzakis, A   +8 more
core  

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Fabrication and characterization of electrospun polycaprolactone/<i>Urechis unicinctus</i> derived-ECM composite scaffolds for small-diameter vascular grafts. [PDF]

RSC Adv
Mun J, Pack SP, Lee H.
europepmc   +1 more source