Results 221 to 230 of about 953,280 (294)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

open access: yesAdvanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu   +11 more
wiley   +1 more source

µSlicer for Programmable Multimaterial 3D Printing

open access: yesAdvanced Science, EarlyView.
ABSTRACT Nature rarely builds with uniform materials; instead, it achieves exceptional performance by arranging composition and structure across multiple length scales. Mimicking such architectures has become increasingly feasible with additive manufacturing, and especially with multimaterial 3D printing, where complex structures with spatially varying
Daniel H. Meile   +5 more
wiley   +1 more source

Engineering a Bioelectronic Hybrid Heart with Integrated Sensing and Electrical Modulation

open access: yesAdvanced Science, EarlyView.
A bioelectronic hybrid heart is engineered by integrating iPSC‐derived cardiomyocytes, a decellularized cardiac scaffold, a cell‐laden ECM coating, and a flexible electronic mesh. The embedded electrodes enable real‐time recording of spontaneous electrical activity and localized stimulation, allowing controlled pacing and modulation of activation ...
Itai Cabilly   +7 more
wiley   +1 more source

A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery

open access: yesAdvanced Science, EarlyView.
A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu   +16 more
wiley   +1 more source

Stage‐Adaptive Bilayer Hydrogel Coordinates Photodynamic Antibacterial Therapy with Engineered Extracellular Vesicle–Mediated Immunomodulation in Infected Diabetic Wounds

open access: yesAdvanced Science, EarlyView.
Early photodynamic infection control and subsequent immunoregulatory repair are spatially separated within a stage‐adaptive bilayer hydrogel. Chlorin e6 is incorporated into the wound‐contacting layer to provide light‐triggered bactericidal therapy, whereas the upper layer regulates excessive reactive oxygen species before releasing microRNA‐146a ...
Gaofei Zhang   +8 more
wiley   +1 more source

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