Results 221 to 230 of about 107,348 (285)

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

open access: yesAdvanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab   +14 more
wiley   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

open access: yesAdvanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita   +4 more
wiley   +1 more source

Targeted therapies for vascular malformations. [PDF]

open access: yesFront Med (Lausanne)
Kane G, Fernandez-Pineda I.
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Artificial Piezoelectric Interface Enables Ultrafast Interfacial Ion Kinetic for Highly‐Sensitive Piezoionic Sensors

open access: yesAdvanced Science, EarlyView.
This study proposes a piezoelectric interface modification strategy to amplify the piezoionic effect. The piezoelectric interface generates an intrinsic electric field, which not only drives rapid ion migration but also concentrates polarized ions on the interface. The flexible sensor delivers superior performance, such as a quick response rate, strong
Yanyu Chen   +5 more
wiley   +1 more source

Somatic Uniparental Disomy of PTEN in Endothelial Cells Causes Vascular Malformations in Patients with PTEN Hamartoma Tumor Syndrome. [PDF]

open access: yesCancer Discov
Castillo SD   +21 more
europepmc   +1 more source

Volcano‐Inspired Dual‐Carbon Network Aerogel for High‐Performance Solar Evaporation With Edge‐Directed Salt Crystallization and Recovery

open access: yesAdvanced Science, EarlyView.
A volcano‐inspired dual‐carbon aerogel featuring hierarchical conduits and an outer carbon‐fiber shell directs rapid water transport, confines heat, and enables directional salt migration. Radial temperature gradients in the conical structure trigger Marangoni‐driven edge‐localized salt crystallization while maintaining an unobstructed photothermal ...
Shuyue Feng   +8 more
wiley   +1 more source

4D flow MRI for noninvasive monitoring of high-flow vascular malformations in neonates and infants: A feasibility study. [PDF]

open access: yesInterv Neuroradiol
Massachi JA   +9 more
europepmc   +1 more source

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