Results 321 to 330 of about 708,976 (400)

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition. [PDF]

Aging (Albany NY)
Razazian M, Bahiraii S, Sohail A, Mandl M, Jannat I, Beilhack G, Alesutan I, Voelkl J.   +7 more
europepmc   +1 more source

Lutetium‐Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR‐II Fluorescence Imaging‐Guided Surgery in Colorectal Cancer

Advanced Science, EarlyView.
Enhancing radiosensitization, modulating the tumor immune microenvironment, and ensuring complete resection are crucial for colorectal cancer (CRC) treatment. This study presents a multifunctional NIR‐II fluorescent nanoprobe, RVLu@ICG, which enhances radiosensitization, remodels the tumor immune microenvironment, and enables precise image‐guided ...
Yongying Dang, Xianzhi Liu, Zifan Zheng, Ao Wang, Ying Huang, Zhong Luo, Haina Tian, Siyaqi Li, Qiang Luo, Peiyuan Wang, Weiling He   +10 more
wiley   +1 more source

Aldosterone-Induced Transformation of Vascular Smooth Muscle Cells into Macrophage-like Cells Participates in Inflammatory Vascular Lesions. [PDF]

Int J Mol Sci
Zhang B, Liu Z, Chang Y, Lv R, Guo H, Qiang P, Shimosawa T, Xu Q, Yang F.   +8 more
europepmc   +1 more source

Graphene‐Based Oscillators for Biomimetic Neuro‐Interfaces

Advanced Electronic Materials, EarlyView.
Graphene oxide membranes combined with polyelectrolytes form ionic transistors that generate oscillatory ion currents, mimicking neuronal signaling. These low‐voltage devices synchronize Ca2+ flux, modulate vascular smooth muscle contraction, and integrate into multivibrator circuits, offering a bioinspired platform for neuromorphic electronics and ...
Konstantin G. Nikolaev, Sergey Grebenchuk, Zhao Jinpei, Kou Yang, Yixin Zhang, Ong Mei Shan, Vitaly Sorokin, Siyu Chen, Qian Wang, Jia Hui Bong, Kostya S. Novoselov, Daria V. Andreeva   +11 more
wiley   +1 more source

Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro. [PDF]

Sci Rep
Shen A, Wu M, Guo Z, Ali F, Wu J, Chen H, Cheng Y, Lian D, Peng J, Yu M, Chen K.   +10 more
europepmc   +1 more source

Long‐Term Nutritional Benefits of Laparoscopic Pancreatoduodenectomy Over Open Surgery

Annals of Gastroenterological Surgery, EarlyView.
Minimally invasive laparoscopic pancreaticoduodenectomy (LPD) significantly improves long‐term nutritional outcomes compared to open pancreaticoduodenectomy (OPD). LPD patients demonstrated better preservation of muscle mass index (PMI) and a lower incidence of postoperative fatty liver.
Koki Kurahashi, Takayuki Anazawa, Kei Yamane, Kazuyuki Nagai, Satoshi Ishida, Satoshi Ogiso, Yoichiro Uchida, Takashi Ito, Takamichi Ishii, Etsuro Hatano   +9 more
wiley   +1 more source

Protocatechuic Acid Attenuates Inflammation in Macrophage-like Vascular Smooth Muscle Cells in ApoE^-/- Mice. [PDF]

Nutrients
Li S, Du Y, Chen G, Mao Y, Zhang W, Kang M, Zhu S, Wang D.   +7 more
europepmc   +1 more source

Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue

Advanced Intelligent Systems, EarlyView.
A scalable, monolithic biohybrid flexure mechanism is presented, integrating engineered skeletal muscle tissue with a soft, biocompatible, hollow silicone cylinder featuring dual pillars. Muscle contraction induces bending motion upon electrical stimulation, with performance governed by the structure's flexural rigidity.
Andrea Bartolucci, Judith Fuentes, Daniele Guarnera, Florencia Lezcano, Maria Crespo‐Cuadrado, Lorena Guachi‐Guachi, Francesco Iacoponi, Carlotta Salvatori, Riccardo Collu, Massimo Barbaro, Stefano Lai, Leonardo Ricotti, Samuel Sánchez, Lorenzo Vannozzi   +13 more
wiley   +1 more source

Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells. [PDF]

J Clin Invest
Cuibus MA, Abdel-Wahab O.
europepmc   +1 more source