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Mechanics of Vascular Smooth Muscle
Comprehensive Physiology, 2016ABSTRACTVascular smooth muscle (VSM; see Table 1 for a list of abbreviations) is a heterogeneous biomaterial comprised of cells and extracellular matrix. By surrounding tubes of endothelial cells, VSM forms a regulated network, the vasculature, through which oxygenated blood supplies specialized organs, permitting the development of large multicellular
P. Ratz
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Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
Physiological Reviews, 2004The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normal development and maturation of the vasculature, as well
G. Owens, Meena S. Kumar, B. Wamhoff
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Leptin and Vascular Smooth Muscle
Current Vascular Pharmacology, 2006Leptin has received extensive attention as an endogenously produced satiety factor. Although once considered to be solely derived from adipose tissue, it is now apparent that leptin can be produced by various tissues including those comprising the cardiovascular system such as blood vessels and cardiomyocytes. Moreover, leptin receptors (OBR) have been
Asad Zeidan, Morris Karmazyn
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Vascular Smooth Muscle Energetics
Journal of Cardiovascular Pharmacology, 1984ATP utilization (delta approximately P) during an isometric contraction has been studied in terms of both measurements of oxygen consumption and lactate production as well as of the tissue nucleotide and metabolite levels. The contribution of breakdown of preformed ATP and phosphocreatine (PCr) pools to delta approximately P during contraction is minor
Richard J. Paul +2 more
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2005
Vascular smooth muscle cells (VSMCs) are a major component of arteries, veins and small blood vessels. Their main function is to maintain vascular tone, via co-ordinated vasoconstriction and vasorelaxation, thereby regulating blood pressure and flow.
Diane Proudfoot, Catherine M. Shanahan
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Vascular smooth muscle cells (VSMCs) are a major component of arteries, veins and small blood vessels. Their main function is to maintain vascular tone, via co-ordinated vasoconstriction and vasorelaxation, thereby regulating blood pressure and flow.
Diane Proudfoot, Catherine M. Shanahan
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Mechanotransduction by Vascular Smooth Muscle
Journal of Vascular Research, 1995Mechanotransduction by vascular smooth muscle (VSM) is defined as a cellular response (contraction, secretion, growth, division) to transmural pressure or stretch. This review includes an overview of the physical forces VSM cells experience in vivo, consideration of experimental techniques used to study VSM mechanotransduction, and a discussion of the ...
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Leptin and Vascular Smooth Muscle Cells
Current Pharmaceutical Design, 2014This review concerns the influence of leptin on vascular smooth muscle cells (VSMC). VSMC express different isoforms of the leptin receptor (Ob-R) able to activate a wide range of intracellular signalling pathways, mediating many relevant biological actions.
TROVATI, Mariella +5 more
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Actions of Nicorandil on Vascular Smooth Muscles
Journal of Cardiovascular Pharmacology, 1987The action of nicorandil on vascular smooth muscles has been studied in vitro using the microelectrode, Ca-transient, isometric tension recording methods, and the bioassay methods of cyclic nucleotides and inositol phospholipids. Nicorandil increased Ca-insensitive K conductance and hyperpolarized the membrane and thus prevented the activation of the ...
Hirosi Kuriyama +6 more
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Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.
Circulation Research, 2015RATIONALE Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is specifically loaded into MVs.
A. Kapustin +19 more
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Vascular Smooth Muscle Calcium Channels
Journal of Cardiovascular Pharmacology, 1987Vascular smooth muscle Ca channels function in excitation-contraction coupling. A survey of recent literature reveals several types of excitable Ca channels. There are at least two plasmalemmal Ca channels that are primarily activated by depolarization. In addition, there also exists evidence for the presence of Ca channels in conduit arteries that are
H. Yamamoto +3 more
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