Results 101 to 110 of about 2,851,022 (307)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Lumbar Sympathetic Radiofrequency Ablation for Peripheral Arterial Disease: A Short-Term, Self-Controlled, Retrospective Pilot Study of 16 Patients [Response To Letter]

Journal of Pain Research
FanZhen Lv,1,* Yue Lin,1,* Xinsheng Xie,1 Yulong Huang,1 Gang Chen,1 Shichai Hong,1 Xiang Hong,1 WeiGuo Fu,1,2 Weifeng Lu11Department of Vascular Surgery, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, People& ...
Lv F, Lin Y, Xie X, Huang Y, Chen G, Hong S, Hong X, Fu W, Lu W   +8 more
doaj  

Surgical Treatment of a Severe Electrolyte Imbalance: A Case Report of an Elderly Patient With McKittrick–Wheelock Syndrome

Case Reports in Surgery
McKittrick–Wheelock is a rare syndrome characterized by a severe, difficult to correct electrolyte imbalance, chronic mucus diarrhea, and a large rectal polyp. In this case report, we describe an elderly patient diagnosed with a large nonmalignant rectal
Piotr Roman Więckowski, Joanna Matylda Łysak, Jakub Blicharz, Maciej Dudziński, Piotr Sienkiewicz   +4 more
doaj   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Lumbar Sympathetic Radiofrequency Ablation for Peripheral Arterial Disease: A Short-Term, Self-Controlled, Retrospective Pilot Study of 16 Patients

Journal of Pain Research
FanZhen Lv,1,* Yue Lin,1,* Xinsheng Xie,1 Yulong Huang,1 Gang Chen,1 Shichai Hong,1 Xiang Hong,1 WeiGuo Fu,1– 3 Weifeng Lu11Department of Vascular Surgery, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, 361015, People’s ...
Lv F, Lin Y, Xie X, Huang Y, Chen G, Hong S, Hong X, Fu W, Lu W   +8 more
doaj  

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

The Vascular Interventions and Surgery in Trauma Audit (VISTA): A Prospective National Service Evaluation of Vascular Trauma in the UK

Objective The frequency, operative management, and outcomes for patients with traumatic vascular injury in the UK are unknown. The Vascular Interventions and Surgery in Trauma Audit (VISTA) aimed to describe the contemporary landscape of UK vascular ...
Simon, G, Davenport, R, hurndall, K
core   +1 more source

A New Bioactive Glass‐Based Hybrid Bioink With Enhanced Cell Viability and Antibacterial Properties

Advanced Healthcare Materials, EarlyView.
Graphical illustration of the production and characterization process, demonstrating the multiple functions of the new hybrid gelatin methacryloyl‐silver‐bioactive glass (GAB) material. Created in https://BioRender.com. ABSTRACT Recent advances in three‐dimensional bioprinting (3DBP) technology enable the production of customized bone substitutes ...
Adam C. Marsh, Ehsanul Hoque Apu, Theofania Kleisoura, Romila Manchanda, Valerie Johnson, Ginger Ross, Ioannis Tsamesidis, Eleana Kontonasaki, DeMarcus Bunn, Ahmet Erdem, Neal D. Hammer, Kurt D. Hankenson, Christopher H. Contag, Nureddin Ashammakhi, Xanthippi Chatzistavrou   +14 more
wiley   +1 more source

Zizhu Ointment Inhibits IgE–FcεRI Signaling-Mediated Mast Cell Degranulation to Promote the Healing of Diabetic Foot Ulcers

Journal of Diabetes Research
Diabetic ulcers, a serious complication associated with diabetes, present a significant therapeutic challenge due to their recurrent and persistent chronic inflammation.
Jian Sun, Xiaoqian Zhang, Meijie Yuan, Xiao Yang, Lei Wang, Hongshuo Shi, Guobin Liu, Yang You   +7 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source