Results 51 to 60 of about 240,544 (274)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Usefulness of microsurgical back‐table angioplasty for multiple hepatic arteries in living donor liver transplantation

Annals of Gastroenterological Surgery, 2020
The graft hepatic artery orifice is tiny in living donor liver transplantation, and therefore, it is more difficult to reconstruct the hepatic artery than in deceased donor liver transplantation.
Noboru Harada, Tomoharu Yoshizumi, Toshiharu Matsuura, Tomoaki Taguchi, Masaki Mori   +4 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Complications of use of vascular devices during the covid-19 pandemic: a retrospective cohort [PDF]

Jornal Vascular Brasileiro
Background During the COVID-19 pandemic, there was a substantial increase in the number of severely ill hospitalized patients, which coincided with a corresponding increase in the consumption of medical supplies, including vascular devices.
Johann Viktor Müller, Wander Eduardo Sardinha, José Manoel da Silva Silvestre, Guilherme da Silva Silvestre, Ualid Saleh Hatoum, Natália Scaneiro Boy Sardinha, Renne Rodrigues, Mariana Ragassi Urbano   +7 more
doaj   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

EFFICACY OF THE ENDOVASCULAR TREATMENT OF THE THORACIC AND ABDOMINAL AORTIC ANEURYSMS IN CARTAGENA, COLOMBIA

Revista Ciencias Biomédicas, 2015
Introduction: The aortic aneurysms (AA) are a segmentary and permanent dilatation of the aorta that could end in a catastrophic outcome named acute aortic syndrome (AAS), which could curse with rupture and in most cases in death.
Marzola-Peña Katy, Arrieta-Usta Micaela
doaj  

Estudo experimental de reconstrução da veia femoral com enxerto tubular do bipolímero de cana-de-açúcar.

Revista do Colégio Brasileiro de Cirurgiões, 2018
RESUMO Objetivo: avaliar, através de dopplerfluxometria, de venografia, de histologia e de evolução clínica, o uso de enxertos tubulares de biopolímero de cana-de-açúcar (BP) na reconstrução de veias femorais em cães.
Daniella Maria Souza Silva, Esdras Marques Lins, Sílvio Romero Barros Marques, Amanda Vasconcelos Albuquerque, José Lamartine Andrade Aguiar   +4 more
doaj   +1 more source

Minimal-invasive, video-assisted vein harvesting for cardiac and vascular surgical procedures [PDF]

European Journal of Cardio-Thoracic Surgery, 1997
Harvesting of the saphenous vein is a routine procedure in coronary and peripheral vascular surgery. It is usually performed using a continuous long skin incision. Minor complications are reported in up to 24% (hematoma, wound dehiscence, infection, pain) and major problems necessitating surgical interventions (bleeding, abscess) in less than 1%. These
J. Schöllhorn, Friedhelm Beyersdorf, Georg Lutter, Christoph Lutz, C Schlensak   +4 more
openaire   +4 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source