Results 181 to 190 of about 7,952,783 (243)
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Nature Reviews Cancer, 2005
It is now accepted that the growth of solid tumours is dependent on their capacity to acquire a blood supply, and much effort has been directed towards the development of agents (known as anti-angiogenics) that disrupt this process. More recently, it has become apparent that targeted destruction of the established tumour vasculature is another avenue ...
D. Neri, R. Bicknell
semanticscholar +3 more sources
It is now accepted that the growth of solid tumours is dependent on their capacity to acquire a blood supply, and much effort has been directed towards the development of agents (known as anti-angiogenics) that disrupt this process. More recently, it has become apparent that targeted destruction of the established tumour vasculature is another avenue ...
D. Neri, R. Bicknell
semanticscholar +3 more sources
International Journal of Biological Macromolecules, 2023
Oral nanoparticles (NPs) are more suitable for obesity control compared to NPs administered intravenously, as their convenience increases patient compliance. Herein, we developed an oral nano-system to improve the anti-obesity efficacy of celastrol (Cel).
Jing Xian +10 more
semanticscholar +1 more source
Oral nanoparticles (NPs) are more suitable for obesity control compared to NPs administered intravenously, as their convenience increases patient compliance. Herein, we developed an oral nano-system to improve the anti-obesity efficacy of celastrol (Cel).
Jing Xian +10 more
semanticscholar +1 more source
Current Oncology Reports, 2004
The role of the vascular network of a tumor has been the focus of much recent research. Angiogenesis, or the growth of new tumor blood vessels, was initially the main target in the development of novel antitumor agents. More recently, new therapeutic strategies have been designed to destroy established tumor blood vessels.
Mary Jo, Pilat +2 more
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The role of the vascular network of a tumor has been the focus of much recent research. Angiogenesis, or the growth of new tumor blood vessels, was initially the main target in the development of novel antitumor agents. More recently, new therapeutic strategies have been designed to destroy established tumor blood vessels.
Mary Jo, Pilat +2 more
openaire +2 more sources
Inflammation-targeted vascular nanomedicine
Nature Biomedical Engineering, 2018Lipoprotein nanoparticles delivering an inflammation-targeting signalling inhibitor reduce vascular inflammation in atherosclerotic mice.
John P, Cooke, Mauro, Ferrari
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Combination Vascular Targeted and Tumor Targeted Radioimmunotherapy
Cancer Biotherapy and Radiopharmaceuticals, 1999Rat MAb 201B, which binds to murine thrombomodulin, can deliver up to 50% of the injected dose of attached radioisotopes to the lung vascular endothelium. We have shown previously that intravenous injection of about 30 microCi of 213Bi-MAb 201B, which delivers about 15 Gy of alpha irradiation to the lung, is capable of eradicating small lung colonies ...
S J, Kennel +5 more
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The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2007
The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary
J, Ahlskog, G, Paganelli, D, Neri
openaire +3 more sources
The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary
J, Ahlskog, G, Paganelli, D, Neri
openaire +3 more sources
Science, 2014
Manipulating metabolism could control ...
Lee B. Rivera, Gabriele Bergers
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Manipulating metabolism could control ...
Lee B. Rivera, Gabriele Bergers
openaire +1 more source
Drugs of the Future, 2006
Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
openaire +1 more source
Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
openaire +1 more source
Hepatology, 2018
Increased vascular permeability facilitates metastasis. Emerging evidence indicates that secreted microRNAs (miRNAs) may mediate the crosstalk between cancer and stromal cells. To date, whether and how secreted miRNAs affect vascular permeability remains
Jian‐Hong Fang +6 more
semanticscholar +1 more source
Increased vascular permeability facilitates metastasis. Emerging evidence indicates that secreted microRNAs (miRNAs) may mediate the crosstalk between cancer and stromal cells. To date, whether and how secreted miRNAs affect vascular permeability remains
Jian‐Hong Fang +6 more
semanticscholar +1 more source
Vascular targeting and antigen presentation
Nature Immunology, 2001The activation of macrophages, dendritic cells and other APCs depends on antigen binding to membrane surface receptors followed by internalization, intracellular processing and presentation. Several recent studies have focused on antigen targeting to APCs1, 2, 3. Two different approaches have been explored.
R, Pasqualini, D M, McDonald, W, Arap
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