Results 191 to 200 of about 7,952,783 (243)

Vascular-targeted cancer gene therapy

Expert Opinion on Biological Therapy, 2004
As a consequence of the dramatic progress that has been made in recent years towards elucidating the diverse molecular events involved in the development and pathogenesis of malignant disease, there is now no shortage of genes that can be exploited or targeted in the context of cancer gene therapy.
Graeme J, Dougherty, Peter D, Davis, Shona T, Dougherty   +2 more
openaire   +2 more sources

Polysaccharides for Vascular Cell Targeting

Critical Reviews™ in Therapeutic Drug Carrier Systems, 2000
Carbohydrate structures are involved in numerous biological activities such as inflammation, and cell adhesion/migration/proliferation. This gives the rationale for the design of vascular targeted drug delivery systems bearing sugar moieties. For the imaging and treatment of vascular diseases, an overview is presented with polysaccharides targeting ...
C, Blondin, I, Bataille, D, Letourneur
openaire   +2 more sources

Biology and therapeutic targeting of vascular endothelial growth factor A

Nature reviews. Molecular cell biology, 2023
Lorena Pérez-Gutiérrez, N. Ferrara
semanticscholar   +1 more source

Targeting Vascular Niche by Parathyroid Hormone

Current Medicinal Chemistry, 2008
Currently, the parathyroid hormone (PTH) is a drug approved for use in humans only in bone metabolism diseases, as the osteoporosis. The PTH acts primarily by binding to its principal receptor, PTH/PTHrP-R, a member of the class B G protein-coupled receptor (GPCR) family that includes together receptors for other therapeutically important peptide ...
PAGLIARULO C, SALVATORE P, NAPOLI, Claudio   +2 more
openaire   +4 more sources

Targeting vascular calcification: softening-up a hard target

Current Opinion in Pharmacology, 2009
Widespread vascular calcification is a ubiquitous feature of aging and is prevalent in association with a number of common pathologies including atherosclerosis, renal failure, and diabetes. Once thought of as innocuous, emerging evidence suggests that calcification is causal in precipitating vascular events and mediating chronic cardiovascular damage,
Kapustin, Alexander, Shanahan, Catherine M.   +1 more
openaire   +3 more sources

Newer vascular targets: Endosialin (Review)

International Journal of Oncology, 2007
The identification of cell surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene expression analysis.
openaire   +2 more sources

Vascular targeting via caveolae

Nature Biotechnology, 2007
Live imaging reveals that caveolae mediate rapid transport of antibodies across the lung endothelium.
Kristy Red-Horse, Napoleone Ferrara
openaire   +1 more source

Antibody-Based Vascular Tumor Targeting

2009
The inhibition of angiogenesis represents a major step toward a more selective and better-tolerated therapy of cancer. An alternative way to take advantage of a tumor's absolute dependence on a functional neovasculature is illustrated by the strategy of "antibody-based vascular tumor targeting." This technology aims at the selective delivery of ...
Christoph, Schliemann, Dario, Neri
openaire   +2 more sources

Newer Vascular Targets

2008
The identification of cell-surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene-expression analysis.
openaire   +1 more source

Combination of nanotechnology with vascular targeting agents for effective cancer therapy

Journal of Cellular Physiology, 2018
Rana Jahanban-Esfahlan, K. Seidi, Behnaz Banimohamad-Shotorbani, Ali Jahanban-Esfahlan, B. Yousefi   +4 more
semanticscholar   +1 more source