Results 61 to 70 of about 261,578 (285)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. [PDF]

, 2013
BACKGROUND Among trauma patients who survive to reach hospital, exsanguination is a common cause of death. A widely practicable treatment that reduces blood loss after trauma could prevent thousands of premature deaths each year.
Ramos, M., Coats, T., T Coats, M Ramos, Perel, P, T Kawahara, Cook, L, Roberts, I., Kawahara, T, Hunt, B, C Guerriero, B Hunt, Barnetson, L, Ramos, M, Kawahara, T., Cook, L., Guerriero, C, I Roberts, E Balogun, Cairns, J, Barnetson, L., Cairns, J., Balogun, E, Prieto-Merino, D, Perel, P., Hunt, B., Coats, T, Balogun, E., L Cook, P Perel, Prieto-Merino, D., H Shakur, D Prieto-Merino, Guerriero, C., J Cairns, Shakur, H, Shakur, H., Roberts, I, L Barnetson   +38 more
core   +1 more source

Can Mangled Extremity Scoring System (MESS) solve the mess of vascular trauma

Indian Journal of Vascular and Endovascular Surgery, 2020
Introduction: Trauma is the new scourge of humankind as without utmost and urgent care, it can result in the loss of limb and life. Civilian trauma is mostly caused by road traffic accidents with resultant skeletal, vascular, and neurological injuries ...
Shamayal Rabbani, Mohd Azam Haseen, Amjad Ali Rizwi, Mohd Hanif Beg   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Visceral mobilization maneuvers in abdominal vascular trauma

Archivo Médico de Camagüey, 2021
Background: abdominal vascular trauma is a challenge for the surgeon. Vascular control is a sine qua non condition in patients who receive surgical intervention against this lethal pathology, where visceral mobilization maneuvers are a key tool in ...
Miguel Emilio García-Rodríguez, Miguel Javier García-Basulto, Raul Koelig-Padrón, Arian Benavidez-Márquez   +3 more
doaj  

Terror attacks increases the risk of vascular injuries

Frontiers in Public Health, 2014
Objectives: Extensive literature exists about military trauma as opposed to the very limited literature regarding terror-related civilian trauma. However, terror-related vascular trauma (VT), as a unique type of injury, is yet to be addressed.Methods: A ...
Eitan eHeldenberg, Adi eGivon, Daniel eSimon, Arie eBass, Gidon eAlmogy, Kobi ePeleg, Kobi ePeleg   +6 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

VASCULAR INJURIES IN TEHRAN: A REVIEW OF 123 CASES [PDF]

Acta Medica Iranica, 2006
- Studies of the epidemiology of civilian vascular trauma in developing countries are rather few. This is a prospective study of our experience with vascular trauma in a referral university hospital in Tehran, Iran.
J. Salimi, M. Karbakhsh M. R. Zarei   +1 more
doaj   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Existing trauma and critical care scoring systems underestimate mortality among vascular trauma patients

, 2010
BackgroundThe impact of vascular injuries on patient mortality has not been well evaluated in multi-trauma patients. This study seeks to determine (1) whether the presence of vascular trauma negatively affects outcome compared with nonvascular trauma ...
Rockman, Caron B., Cayne, Neal S., Pachter, H. Leon, Neal S. Cayne, Christine Chung, Shang A. Loh, Loh, Shang A., Caron B. Rockman, Maldonado, Thomas S., Firas F. Mussa, Chung, Christine, Thomas S. Maldonado, H. Leon Pachter, Adelman, Mark A., Mark A. Adelman, Mussa, Firas F.   +15 more
core   +1 more source