Results 71 to 80 of about 273,619 (385)

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.

Rheumatology, 2019
OBJECTIVES IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and ...
S. Ozen, S. Marks, P. Brogan, N. Groot, N. de Graeff, T. Avčin, B. Bader-Meunier, P. Doležalová, B. Feldman, I. Koné-Paut, P. Lahdenne, L. McCann, C. Pilkington, A. Ravelli, A. van Royen, Y. Uziel, B. Vastert, N. Wulffraat, S. Kamphuis, M. Beresford   +19 more
semanticscholar   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, EarlyView.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification. .
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Cutaneous small vessel vasculitis

Definitions, 2020
Cutaneous leukocytoclastic angiitis is a small-vessel vasculitis presenting with palpable purpura and urticarial lesions which predate the purpuric lesions most frequently observed on the legs.

semanticscholar   +1 more source

Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System—A Multicenter Cohort Study in 163 Patients

Annals of Neurology, EarlyView.
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospective, observational cohort study, we analyzed 163 adult patients who met the diagnostic criteria for PACNS.
Anna Lena Fisse, Nadine Bonberg, Carolin Beuker, Claudia Pfeuffer, Andreas Heidenreich, Christina Krüger, Milani Deb‐Chatterji, Jana Becker, Stefan T. Gerner, Clemens Küpper, Louisa Nitsch, Roxane‐Isabelle Kestner, Lars Udo Krause, Juliane Herm, Alexander Katalinic, André Karch, Ralf Gold, Heinz Wiendl, Wolf‐Rüdiger Schäbitz, Gabor C. Petzold, Waltraud Pfeilschifter, Marius Ringelstein, Thorsten R. Doeppner, Lars Kellert, Hagen B. Huttner, Markus Kraemer, Tim Magnus, Karl Georg Haeusler, Heike Minnerup, Jens Minnerup   +29 more
wiley   +1 more source

FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC

European Journal of Nuclear Medicine and Molecular Imaging, 2018
Large vessel vasculitis (LVV) is defined as a disease mainly affecting the large arteries, with two major variants, Takayasu arteritis (TA) and giant cell arteritis (GCA).
R. Slart, Riemer H. J. A. Andor W. J. M. Panithaya Giorgio Florent Slart Glaudemans Chareonthaitawee Treglia Besson B, R. Slart, A. Glaudemans, P. Chareonthaitawee, G. Treglia, F. Besson, T. Bley, D. Blockmans, R. Boellaard, J. Bucerius, J. Carril, Wengen Chen, M. Cid, Bhaskar Dagupta, S. Dorbala, O. Gheysens, F. Hyafil, Shaifali Jain, T. Klink, C. J. van der Laken, F. Lomeña, M. Massollo, S. Prieto-González, R. Luqmani, A. Roivainen, C. Salvarani, A. Saraste, M. Schirmer, H. Verberne, A. Versari, A. Voskuyl, M. Walter, D. Camellino, E. Brouwer, M. Cimmino, Aiden Denis Rob S. Roberto C. Andrew J. Alessia Edward J Abidov Agostini Beanlands Delgado-Bolton Einstein , A. Abidov, D. Agostini, R. Beanlands, R. Delgado-Bolton, A. Einstein, A. Gimelli, E. Miller, R. Sciagrà, A. Signore, Riemer H. J. A. Jan Fabien Hein J. Denis Alessia Roberto Slart Bucerius Hyafil Verberne Agostini Gimelli Sc, Andor W. J. M. Giorgio Olivier Annibale Alberto Glaudemans Treglia Gheysens Versari Signore, Panithaya Wengen Sharmila Chareonthaitawee Chen Dorbala, Andor W. J. M. Giorgio Florent L. Thorsten A. Daniel Ron Glaudemans Treglia Besson Bley Blockmans Boellaard, A. Roivainen, Panithaya Sharmila Aiden Rob S. Andrew J. Edward J. Chareonthaitawee Dorbala Abidov Beanlands Einstein   +51 more
semanticscholar   +1 more source

Familial vasculitides: granulomatosis with polyangitis and microscopic polyangitis in two brothers with differing anti-neutrophil cytoplasm antibody specificity [PDF]

, 2016
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a group of rare autoimmune diseases. Although the aetiology of AAV is uncertain, it is likely that genetic and environmental factors contribute.
Cairns, T, Prendecki, M, Pusey, CD
core   +1 more source

Clinical Factors Associated With Pneumocystis Pneumonia Despite Its Primary Prophylaxis: When to Stop Prophylaxis?

Arthritis &Rheumatology, EarlyView.
Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim, Se Rim Choi, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Jun Won Park   +5 more
wiley   +1 more source

Vasculitis

Hospital-Based Dermatopathology, 2020
Vasculitis, characterized by inflammation and necrosis, manifests a wide spectrum of presentation by involving a vasculature of various sizes and locations.
Mai P. Hoang, J. Park
semanticscholar   +1 more source