Results 151 to 160 of about 146,147 (346)

TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates Gq Protein–Coupled Receptor–Induced Vasoconstriction

open access: yesArteriosclerosis, Thrombosis and Vascular Biology, 2018
Kwangseok Hong   +5 more
semanticscholar   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi   +4 more
wiley   +1 more source

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes

open access: yesScience Signaling, 2017
Matthew A. Nystoriak   +14 more
semanticscholar   +1 more source

The use of octreotide in pediatric patients: Practical applications for gastrointestinal disorders and beyond: A narrative review

open access: yesNutrition in Clinical Practice, EarlyView.
Abstract Somatostatin is a naturally occurring polypeptide hormone that exerts its effect on the gastrointestinal tract by reducing exocrine and endocrine secretion, resulting in decreased motility, gastric emptying, splanchnic blood flow, fat absorption, lymphatic flow, and gallbladder contraction.
Bailey Dunn   +4 more
wiley   +1 more source

Decreased multidrug resistance protein 1 and increased platelet activation in obstructive sleep apnea syndrome

open access: yesSleep Research, EarlyView.
There was a positive correlation between apnea/hypopnea index (AHI) index and platelet aggregation and a negative correlation between CD42b and multidrug resistance protein 1 (MRP1). Platelet activation was high while MRP1 expression was low in severe obstructive sleep apnea syndrome (OSAS) independent of smoking, age, and gender.
Cigdem Bayram Gurel   +8 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Ulcerative colitis is a chronic immune‐mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate‐to‐severe ulcerative colitis, significantly improving its management.
Massimo C. Fantini   +4 more
wiley   +1 more source

Giant hydronephrosis: A rare cause of secondary hypertension

open access: yesUroPrecision, EarlyView.
Abstract Background Hypertension secondary to giant hydronephrosis (GH) is a rare but treatable renal condition mediated by the renin‐angiotensin‐aldosterone system and tubuloglomerular feedback. In adults, GH is often diagnosed late due to nonspecific abdominal symptoms that may not manifest until advanced stages.
Ganesh Laxman Krishnamurthy   +7 more
wiley   +1 more source

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