Results 211 to 220 of about 146,147 (346)

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira, José Eduardo da Silva‐Santos   +1 more
wiley   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Effects of vasoconstriction and distal dilation on carotid stenoses in the dog. [PDF]

, 1983
William P. Santamore, James H. Wood, A. A. Bove, Pablo M. Lawner   +3 more
openalex   +1 more source

Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling. [PDF]

Elife
Le Gac B, Tournissac M, Belzic E, Picaud S, Dusart I, Soula H, Li D, Charpak S, Cauli B.   +8 more
europepmc   +1 more source

Effects of ergonovine-induced vasoconstriction on the genesis of myocardial ischemia during coronary stenosis in dogs.

, 1983
Susumu Sakamoto, Mitsuhiro Yokoyama, Hozuka Akita, Seinosuke Kawashima, Toshio Okada, Tetsuo Mizutani, Hisashi Fukuzaki   +6 more
openalex   +2 more sources

Inhalation Anesthetics Augment Oxidant-induced Pulmonary Vasoconstriction [PDF]

, 1985
Jay R. Shayevitz, Richard J. Traystman, N. F. Adkinson, Alfred M. Sciuto, G. H. Gurtner   +4 more
openalex   +1 more source

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, EarlyView.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +1 more source

Insights Into the Pathophysiology of Catecholamine-Refractory Shock: A Narrative Review. [PDF]

Cureus
Gonçalves A, Gonçalves Pereira F, Fernandes S, Gonçalves Pereira J.   +3 more
europepmc   +1 more source

Enhanced hypoxic pulmonary vasoconstriction in hypertension.

, 1989
Marco Guazzi, Marina Alimento, Marco Berti, Caterina Fiorentini, C. Galli, Gloria Tamborini   +5 more
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source