Results 31 to 40 of about 103,266 (298)

Hypoxic Pulmonary Vasoconstriction in Humans [PDF]

BioMed Research International, 2013
Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although considerable progress has been made to describe the phenomenon at the macroscopic level and explain it at the ...
Ariyaratnam, Priyadharshanan, Loubani, Mahmoud, Morice, Alyn H.   +2 more
openaire   +3 more sources

A Highly Adaptable Hydrogen Bond Re‐Orientation (HyBRO) Strategy for Multiscale Vasculature Fabrication

Advanced Materials, EarlyView.
A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Zhencheng Liao, Yu Liu, Chonghao Chen, Iek Man Lei, Lei Dong, Chunming Wang   +5 more
wiley   +1 more source

CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca𝟐+ influx and RhoA/Rock pathway in VSMCs

Frontiers in Bioscience-Landmark, 2021
Background: Cystic fibrosis transmembrane conductance regulator (CFTR) has been associated with vascular tone and blood pressure (BP), however, its role in the genesis of hypertension remains elusive.
Liyan Zhao, Feng Yuan, Ni Pan, Yun Yu, Hanyan Yang, Yaosheng Liu, Ruomei Wang, Bin Zhang, Guanlei Wang   +8 more
doaj   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension

Advanced Science, EarlyView.
This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo, Zhenqiang Gao, Ruoyang Zhang, Huanyu Long, Muzhi Zhang, Lin Liu, Zhe An, Yuezhe Shi, Ye Cui, Yufeng Jia, Lei Wang, Ying Sun, Jie Liu, Wei Wang   +13 more
wiley   +1 more source

Dual‐Graded Microstructure Engineering for Flexible Piezoresistive Sensors with High Sensitivity and Broad Linear Range in Physiological Monitoring

Advanced Science, EarlyView.
A flexible piezoresistive pressure sensor with dual‐graded microstructures achieves both high sensitivity (69.8 kPa⁻¹) and a broad linear range up to 300 kPa (R2 = 0.997). Synergizing structural deformation and tunneling conduction, it enables rapid, stable, and accurate detection of subtle physiological signals, offering a scalable and cost‐effective ...
Ningning Bai, Dandan Xu, Zhuang Su, Gangqiang Li, Lilong He, Yanli Chen, Chengxi Guo, Linxuan Zhou, Xianming Qin, Ji Zhang, Daowei Wu, Weidong Wang   +11 more
wiley   +1 more source

Membrane depolarization is required for pressure-dependent pulmonary arterial tone but not enhanced vasoconstriction to endothelin-1 following chronic hypoxia

Pulmonary Circulation, 2020
Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in enhanced Rho kinase mediated Ca 2+ sensitization contributing to pressure-dependent pulmonary ...
Charles E Norton, Nikki L Jernigan, Benjimen R Walker, Thomas C Resta   +3 more
doaj   +1 more source

VASCULAR MECHANISMS OF TRITERPENOID SAPONINS ISOLATED FROM Passiflora quadrangularis L.

Vitae, 2020
Background: Passiflora quadrangularis L. has antihypertensive and anxiolytic properties observed in experimental models. Objectives: The aim of this work was to establish the vascular effects exerted by two known monodesmosidic triterpene saponins, 3-O-β-
Mario Francisco Guerrero Pabón, Lesly L Bareño, Pilar Puebla, Arturo San Feliciano   +3 more
doaj   +1 more source

Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

Pharmaceutics, 2021
Rho-associated kinase (ROCK) activation was shown to contribute to microvascular closure, retinal hypoxia, and to retinal pigment epithelium (RPE) barrier disruption in a rat model of diabetic retinopathy.
Cecile Lebon, Heike Neubauer, Marianne Berdugo, Kimberley Delaunay, Elke Markert, Kolja Becker, Katja S. Baum-Kroker, Jürgen Prestle, Holger Fuchs, Remko A. Bakker, Francine Behar-Cohen   +10 more
doaj   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source