Results 121 to 130 of about 204,625 (386)

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Triptans and CGRP blockade - impact on the cranial vasculature [PDF]

, 2017
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide ...
Alejandro Labastida-Ramírez, Anne Luise Vollesen, Christian Lampl, Francesca Cortese, Francesca Marchese, Lanfranco Pellesi, Messoud Ashina, Michele Romoli, On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Silvia Benemei   +9 more
core   +3 more sources

Treatment With Phosphodiesterase 5 Inhibitors and Long‐Term Outcomes in Patients Undergoing Coronary Angiography and Cardiac Catheterization

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background The effects of phosphodiesterase 5 (PDE5) inhibitors on the incidence of long‐term outcomes in patients with cardiovascular disease are not well understood. Objective: We studied the association between PDE5 inhibitor therapy and the incidence of adverse cardiovascular major adverse cardiovascular events (MACE) in patients ...
Sumon Roy, Annette Min, Edward O. McFalls, Robert A. Perera, Fadi N. Salloum, Ion S. Jovin   +5 more
wiley   +1 more source

The Effect of Salsalate Therapy on Endothelial Function in a Broad Range of Subjects [PDF]

, 2014
Background: Inflammation is fundamental to the development of atherosclerosis. We examined the effect of anti‐inflammatory doses of salicylate on endothelium‐dependent vasodilation, a biomarker of cardiovascular risk, in a broad range of subjects ...
Beckman, Joshua A., Buck, J. Stewart, Copeland‐Halperin, Robert, Kim, Sora, Kinlay, Scott, Nohria, Anju, Redline, Whitney   +6 more
core   +1 more source

Managing Persistent Radial Artery Spasm During Coronary Catheterization: A Complex Case Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT This case report details the management of persistent radial artery spasm during coronary catheterization, unresponsive to standard pharmacotherapy. After conventional methods failed, deep sedation, neuromuscular blockade, and orotracheal intubation proved essential.
Riccardo Mager, Carlo Gaspardone, Rosaria Sofia, Cosmo Godino   +3 more
wiley   +1 more source

Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient

Pathophysiology
High systolic blood pressure and increased blood pressure variability after the onset of ischemic stroke are associated with poor clinical outcomes. One of the key determinants of blood pressure is arteriolar size, determined by vascular smooth muscle ...
Gokhan Yilmaz, Jonathan Steven Alexander
doaj   +1 more source

Capsaicin-Induced Ca2+ Influx and Constriction of the Middle Meningeal Artery [PDF]

, 2014
Research in the past on transient receptor potential cation channel subfamily V member 1 (TRPV1) has been limited to mainly nervous tissue TRPV1 because of the channel’s role in pain perception.
Koide, Masayo, Kotlikoff, Michael I., Manuelyan, Inessa, Shui, Bo, Syed, Arsalan U., Wellman, George C.   +5 more
core   +1 more source

Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs [PDF]

, 2019
The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases.
Dremin, Viktor V., Dunaev, Andrey V., Goltsov, Alexey, Makovik, Irina N., Rafailov, Edik U., Sokolovski, Sergei G., Zherebtsov, Evgeny A., Zherebtsova, Angelina I.   +7 more
core   +3 more sources

Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Matteo Lucchelli, Davide Tommaso Andreis, Mattia Gomarasca, Giovanni Mistraletti   +3 more
wiley   +1 more source

The New Nitric Oxide Donor, FOR 911B, Induces Relaxation in Isolated Rat Aorta Involving the NO/sGC/cGMP Pathway and K⁺ Channels

Receptors
Background: Nitric oxide (NO) is a gaseous molecule considered to be a protagonist in the dilation of blood vessels, and its property and/or bioavailability are reduced in pathophysiological conditions such as cardiovascular diseases.
Mirelly Cunha da Silva, Florêncio Sousa Gouveia Júnior, Thyago Moreira de Queiroz   +2 more
doaj   +1 more source