Results 91 to 100 of about 26,374 (207)

Linking dynamic cerebral autoregulation and inhibitory executive function: Role of modifiable behaviours

open access: yesExperimental Physiology, EarlyView.
Abstract Dynamic cerebral autoregulation (dCA) stabilises cerebral blood flow (CBF) against rapid fluctuations in perfusion pressure and may serve as a key physiological mediator of cognitive function. Inhibitory executive function, a core domain essential for goal‐directed behaviour, is influenced by modifiable lifestyle factors such as physical ...
Hayato Tsukamoto, Damian M. Bailey
wiley   +1 more source

Increases in skin perfusion and blood oxygen in the non‐exercising human limbs during exercise in the heat: Implications for control of circulation

open access: yesExperimental Physiology, EarlyView.
Abstract Blood flow in the inactive limb tissues and skin is widely thought to decline during incremental exercise to exhaustion due to augmented sympathoadrenal vasoconstrictor activity, but direct evidence to support this view is lacking. Here, we investigated the inactive‐forearm haemodynamic (Q̇forearm${\dot{Q}}_{\mathrm{forearm}}$) and oxygenation
Steven J. Trangmar   +1 more
wiley   +1 more source

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

open access: yesExperimental Physiology, EarlyView.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo   +10 more
wiley   +1 more source

Coupling between global brain blood oxygen level‐dependent activity and cerebrospinal fluid dynamics in young endurance athletes

open access: yesExperimental Physiology, EarlyView.
Abstract Cerebrospinal fluid (CSF) contributes to brain waste clearance through its coupling with cerebral haemodynamics. Aerobic exercise promotes brain health, but its influence on brain waste clearance remains unclear. This study examined the coupling between CSF and cerebral haemodynamics in endurance athletes. Fifteen young male endurance athletes
Daisuke Hoshi   +9 more
wiley   +1 more source

Cerebral blood flow regulation, central arterial stiffness and traumatic brain injury: Effects of aerobic exercise training

open access: yesExperimental Physiology, EarlyView.
Abstract Advanced age is the strongest risk factor for Alzheimer's disease and related dementias (ADRDs). Traumatic brain injury (TBI) has also been recognized as a risk factor for ADRD, potentially contributing to an earlier onset of the disease. Thus, elucidating the mechanisms underlying brain ageing and TBI is critical for developing strategies to ...
Tsubasa Tomoto   +3 more
wiley   +1 more source

Quantifying microvascular responses to local heating using optical coherence tomography: Comparison between skin sites and sex differences

open access: yesExperimental Physiology, EarlyView.
Summary of the study design, metholodgy, results and conclusions. Abstract Due to a lack of technical capacity to directly visualise and quantify microvessels in the skin, little is known regarding regional and/or sex differences. We compared diameter, velocity, flow and density at four regional sites using a novel optical coherence tomography (OCT ...
Juliene G. Costa   +5 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

open access: yesExperimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak   +3 more
wiley   +1 more source

Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans

open access: yesExperimental Physiology, EarlyView.
Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts   +13 more
wiley   +1 more source

Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts   +9 more
wiley   +1 more source

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