Results 101 to 110 of about 26,374 (207)

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Role of reactive oxygen species in mediating peripheral hypoxic vasodilation and sympathoexcitation at high altitude

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude acclimatisation increases muscle sympathetic nerve activity (MSNA) via activation of the arterial chemoreflex, pulmonary arterial baroreceptors and resetting of the sympathetic vascular baroreflex. However attempting to silence these mechanisms only partially normalises MSNA, implicating other contributory ...
Liam D. Corr, Andrew J. M. Douglas, Elliott J. Jenkins, Lauren E. Maier, Jodie L. Koep, Travis D. Gibbons, Adam Field, James D. Anholm, Katharine Foster, Zoe H. Adams, Lydia L. Simpson, Jonathan P. Moore, Tinna Traustadottir, Christoph Siebenmann, Joshua C. Tremblay, Mike Stembridge   +15 more
wiley   +1 more source

Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review

Catheterization and Cardiovascular Interventions, Volume 107, Issue 4, Page 869-884, March 1, 2026.
ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet, Siddhartha Mengi, David Garcia Labbé, Can Manh Nguyen, Jean‐Michel Paradis   +4 more
wiley   +1 more source

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Dimitra Eleftheriou, Paul Willem Schenk, Naomi Bertine Klarenbeek, Derek William Gilroy, Manon Aleida Adriana Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

The Regulation of Vasomotor and Cardiorespiratory Pulsations Is Disrupted in Primary Central Nervous System Lymphoma: A Case–Control fMRI Study

Human Brain Mapping, Volume 47, Issue 4, March 2026.
Using fast functional MRI, we assessed low‐frequency oscillations arising from cardiorespiratory pulsations and oscillatory interaction between respiratory and cardiac pulsations in primary central nervous system lymphoma. Respiratory‐related oscillations showed brain‐wide increases with a link to mortality whereas increases in cardiovascular‐related ...
Valter Poltojainen, Matti Järvelä, Nina Keinänen, Michaela K. Bode, Juha‐Matti Isokangas, Hanne Kuitunen, Juha Nikkinen, Vesa Korhonen, Niko Huotari, Lauri Raitamaa, Janne Kananen, Heta Helakari, Tommi Kalevi Korhonen, Sami Tetri, Outi Kuittinen, Vesa Kiviniemi   +15 more
wiley   +1 more source

Considerations for Menstrual Suppression in Patients With Hematologic Malignancies

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Patients who menstruate during treatment for hematologic malignancies have a higher risk of heavy vaginal bleeding due to thrombocytopenia caused by malignancy and myelosuppressive chemotherapy. Heavy menstrual bleeding is associated with significant morbidity in this patient population, and menstrual suppression is a standard of supportive ...
Sahaana Veeravalli, Allison Schepers, Lydia L. Benitez, Martina S. Fraga   +3 more
wiley   +1 more source

Bridging the Gap Between Evidence and Women's Menopausal Experience: Aligning Malaysia's Menopause Guidelines With Cultural, Religious, and Equity Realities (MARIE‐Malaysia WP2a)

Reproductive, Female and Child Health, Volume 5, Issue 1, March 2026.
Abstract Objective Menopause, a universal yet diverse life stage, profoundly influences women's physical, emotional, and social well‐being. In Malaysia's multi‐ethnic context, experiences are shaped by cultural meanings, religious beliefs, healthcare structures, and socioeconomic factors.
Teck‐Hock Toh, Kim‐Yen Lee, Leong‐Hoe Ngu, Juhaida Jaafar, Nor Fareshah Mohd Nasir, Aini Hanan Azmi, Vaitheswariy Rao, Nurul Amalina Jaafar, Siti Nurul Aiman, George Uchenna Eleje, Jie Sun, Julie Taylor, Lucky Saraswat, Sharron Hinchliff, Kristina Potocnik, Kathryn Elliot, Carol Atkinson, Vikram Talaulikar, Nirmala Rathnayake, Tharanga Mudalige, Vindya Pathiraja, Jeevan Dhanarisi, Donatella Fontana, Lamya Al‐Kharusi, Nihal Al‐Riyami, Ieera Madan‐Aggarwal, Helen Felecity Kemp, Victoria Corkhill, Kingshuk Majumder, Ramiya Palanisamy, Muhammad Irfan, Rabia Kareem, Nick Panay, Jian Shi, Sohier Elneil, Peter Phiri, Gayathri Delanerolle, MARIE collaborative   +37 more
wiley   +1 more source

Oral JAK Inhibitors as a Promising Therapeutic Strategy for Refractory Rosacea: A Systematic Review and Meta‐Analysis

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Rosacea is a chronic inflammatory dermatosis. While standard therapies exist, managing refractory subtypes remains a therapeutic challenge. Oral Janus kinase (JAK) inhibitors have emerged as potential alternatives, but systematic evidence is lacking. Aims To evaluate the efficacy and safety of oral JAK inhibitors for rosacea through
Yu Peng, Mingzi Sun, Jiayu Chen, Xubo Huang, Fengchuan Zhang   +4 more
wiley   +1 more source