Results 81 to 90 of about 11,169 (255)

Pharmacokinetics, Bioequivalence, and Safety Studies of Crisaborole Ointment in Healthy Chinese Subjects

open access: yesClinical Pharmacology in Drug Development, Volume 14, Issue 8, Page 614-620, August 2025.
Abstract The aim of this study was to evaluate the bioequivalence and safety of a single application of crisaborole ointment to test formulation and reference formulation in healthy subjects under fasting conditions. A total of 32 subjects were included and divided into 2 groups (test‐reference; reference‐test).
Yanchao Wang   +9 more
wiley   +1 more source

Head-Up Tilt Testing with Different Nitroglycerin Dosages: Experience in Elderly Patients with Unexplained Syncope [PDF]

open access: yes, 2008
AIMS: Protocols using sublingual nitrates have been increasingly used to improve diagnostic accuracy of head-up tilt testing (HUT). Nevertheless, exaggerated responses to nitrates have been frequently described, particularly in elderly patients.
Antunes, E   +7 more
core   +1 more source

Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.
ABSTRACT Background Orthostatic hypotension (OH) is a prevalent condition among older adults, characterised by a sudden drop in blood pressure upon standing, often leading to dizziness and increased risk of falls, morbidity and mortality. The skeletal muscle pump is thought to be important in maintaining venous return and stabilising blood pressure ...
Silvin P. Knight   +3 more
wiley   +1 more source

Endothelial function in vasovagal syncope [PDF]

open access: yesExpert Review of Cardiovascular Therapy, 2014
Vasovagal syncope (VVS) is a common form of fainting. The pathophysiology of VVS is complex and involves changes in the autonomic and vascular tone, resulting in reflex bradycardia with marked hypotension. Paradoxical peripheral vasodilation caused by endothelial dysfunction may also play a key role in inappropriate hypotension during VVS.
openaire   +5 more sources

Spectral analysis of heart rate variability for assessment of autonomic nervous system activity during head-up tilt table testing [PDF]

open access: yes, 2014
Spectral analysis of heart rate variability was used to assess changes in activity of autonomic nervous system (ANS) in 84 patients with history of recurrent syncope and 21 normal controls.
et al., Likar, Polona
core   +1 more source

Etiological diagnosis, prognostic significance and role of electrophysiological study in patients with Brugada ECG and syncope. [PDF]

open access: yes, 2017
BACKGROUND: Syncope is considered a risk factor for life-threatening arrhythmias in Brugada patients. Distinguishing a benign syncope from one due to ventricular arrhythmias is often difficult, unless an ECG is recorded during the episode.
Anselmino, M   +14 more
core   +2 more sources

High‐frequency content within the QRS complex can predict ventricular tachyarrhythmias in hypertrophic cardiomyopathy

open access: yesJournal of Arrhythmia, Volume 41, Issue 4, August 2025.
This study first measured frequency power profiles during the QRS complex (QRS) in HCM patients. The high‐frequency content (150–250 Hz) hidden in the QRS can predict L‐VAs in HCM, even if fragmented or notched QRS is not observed. Abstract Introduction Frequency analysis of the electrocardiographic QRS complex (QRS) was performed to evaluate the ...
Takeshi Tsutsumi   +8 more
wiley   +1 more source

Squatting test: A posture to study and counteract cardiovascular abnormalities associated with autonomic dysfunction. [PDF]

open access: yes, 2011
The squatting test is an active posture manoeuvre that imposes one of the most potent orthostatic stresses. In normal subjects, the changes in blood pressure and heart rate are transient because of appropriate baroreflex homeostasis and do not provoke ...
PHILIPS, Jean-Christophe, SCHEEN, André
core   +1 more source

Extra‐cardiac vagal stimulation: Clinical utility of a novel diagnostic and therapeutic tool in supraventricular tachycardia

open access: yesJournal of Arrhythmia, Volume 41, Issue 4, August 2025.
Extracardiac vagal stimulation (ECVS) is a novel, safe tool inducing controlled AV/VA block. It assists SVT differential diagnosis, pathway unmasking, and ablation endpoint confirmation, adding value to EP procedures for supraventricular tachycardias.
Jose Carlos Pachon‐M   +8 more
wiley   +1 more source

Tilt Test in Elderly Patients with Syncope of Unknown Etiology: Experience with Pharmacological Stimulation with Nitroglycerin [PDF]

open access: yes, 2005
Está demonstrado o papel do teste de inclinação na avaliação de doentes com síncope de causa não esclarecida. Nos idosos, a prevalência de episódios sincopais aumenta, associa-se a pior prognóstico e, frequentemente, implica o recurso a múltiplos exames ...
Antunes, E   +8 more
core  

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