Results 21 to 30 of about 1,611,336 (217)

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

Clinical Pharmacology &Therapeutics, EarlyView.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen, Deena L. Hadi, Daniel A. Todd, Preston K. Manwill, John R. White, Matthew E. Layton, Nadja B. Cech, Kenneth E. Thummel, Mary F. Paine   +8 more
wiley   +1 more source

Geodiversity is an inseparable but underutilized aspect of ecological connectivity assessments under climate change

Ecography, EarlyView.
Conservation has shifted towards a climate change adaptation approach in which expected species range shifts are increasingly considered to mitigate effects of climate change and habitat fragmentation on biodiversity. As part of this, ecological connectivity needs to be ensured to support gene flow and viable populations in the face of changing ...
Aino‐Maija Määttänen, Maria Hällfors, Julia Kemppinen   +2 more
wiley   +1 more source

Powerful yet challenging: mechanistic niche models for predicting invasive species potential distribution under climate change

Ecography, EarlyView.
Risk assessments of invasive species present one of the most challenging applications of species distribution models (SDMs) due to the fundamental issues of distributional disequilibrium, niche changes, and truncation. Invasive species often occupy only a fraction of their potential environmental and geographic ranges, as their spatiotemporal dynamics ...
Erola Fenollosa, Sean E. H. Pang, Natalie J. Briscoe, Antoine Guisan, Roberto Salguero-Gómez   +4 more
wiley   +1 more source

Seasonal Predictions and Their Applications in the Mediterranean Region: Part II—Prediction‐Based Services

International Journal of Climatology, EarlyView.
This review explores climate predictions as actionable decision‐making tools, focusing on the Mediterranean. It examines transforming forecasts into user‐defined information through bias adjustment, downscaling and impact models. Highlighting collaborative EU initiatives, it addresses challenges like limited forecasting skill and data accessibility ...
Silvio Gualdi, Ernesto Rodriguez Camino, Esteban Rodriguez Guisado, Andrea Toreti, Massimiliano Pasqui, Constantin Ardilouze, Wafae Badi, Lauriane Batté, Fatima Driouech, Kristina Fröhlich, Javier García‐Serrano, Silvia Terzago, Veronica Torralba   +12 more
wiley   +1 more source

The role of harms and burdens in clinical practice guidelines: Lessons learned from the American Psychological Association's guideline development

Clinical Psychology: Science and Practice, EarlyView., 2020
Abstract Growing evidence supports the efficacy of various psychosocial interventions yet provides very little information about the potential harms and burdens of treatment. Lacking such information makes it difficult to make truly informed decisions about treatment options.
Raquel W. Halfond, Caroline Vaile Wright, Lynn F. Bufka   +2 more
wiley   +1 more source

From shape to source: sedimentary charcoal morphology as a proxy for tropical burned biomass composition

Journal of Quaternary Science, EarlyView.
ABSTRACT Sedimentary charcoal elongation is increasingly being used in paleoecology to distinguish herbaceous from woody fuel in past fires. However, the relationship between charcoal morphotypes and plant types has never been formally tested in tropical environments, despite its potential to improve understanding of fire regimes and deforestation, and
Fiona Cornet, Vincent Montade, Stéphanie C. Bodin, Justine Descloitre, Maxime Réjou‐Méchain, Gaëlle Viennois, Julie C. Aleman, Chimène Assi‐Kaudjhis, William F. Kenney, Richard Oslisly, Monique G. Tossou, Laurent Bremond, Charly Favier   +12 more
wiley   +1 more source

Indirect effects of fast‐growing urban development on wildlife in a coastal protected area of Costa Rica

The Journal of Wildlife Management, EarlyView.
We studied the effects of urban growth on wildlife near Parque Nacional Marino las Baulas, Costa Rica. Since 1991, buildings increased 1007%, mainly in the buffer zone. We identified eight native species extracting garbage from containers, with raccoons (Procyon lotor) comprising most detections (84%), and four other species being potential sea turtle ...
Keilor E. Cordero‐Umaña, Kortney Stevens, Adam Yaney‐Keller, Javier López Navas, Frank V. Paladino, James R. Spotila, Pilar Santidrián Tomillo   +6 more
wiley   +1 more source

G‐CSF for Mobilizing CD34+ Cells in Individuals With SCD: A Word of Caution

American Journal of Hematology, EarlyView.
Akshay Sharma, Allistair Abraham, Monica Bhatia, María Cancio, Sonali Chaudhury, Selim Corbacioglu, Gregory M. T. Guilcher, Ashish O. Gupta, Rabi Hanna, Matthew M. Heeney, Tami John, Lakshmanan Krishnamurti, James L. LaBelle, Hemalatha G. Rangarajan, Shalini Shenoy, Elizabeth Stenger, Crawford Strunk, Courtney D. Fitzhugh   +17 more
wiley   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium—Update for Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction (SUFU)

Neurourology and Urodynamics, EarlyView.
ABSTRACT The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), has had a successful and productive ten years, accomplishing several major achievements, including over 65 peer‐reviewed publications.
Ariana L. Smith, Siobhan Sutcliffe, for the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium   +2 more
wiley   +1 more source