Results 121 to 130 of about 61,958 (261)
Advanced Science, Volume 13, Issue 11, 23 February 2026.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Advanced Science, Volume 13, Issue 11, 23 February 2026.Spinocerebellar Ataxia Type‐3 Therapies The molecular tweezer CLR01 binds an allosteric site on the Josephin domain of ataxin‐3, reducing conformational flexibility and limiting motions that expose the aggregation‐prone region. Concentric circles evoke the ripple of allosteric modulation extending across biological scales, delaying amyloid formation ...
Alexandra Silva +28 more
wiley +1 more source
Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 391-405, February 2026.ABSTRACT The development of autonomous agents in bioprocess development is crucial for advancing biopharma innovation. Time and resources required to develop and transfer a process for clinical material generation can be significantly decreased. While robotics and machine learning have greatly accelerated drug discovery and initial screening, the later
Chethana Janardhana Gadiyar +10 more
wiley +1 more source
Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture
Chemie Ingenieur Technik, Volume 98, Issue 1-2, Page 57-63, February 2026.Following ISO 20391‐2:2019 guidelines, manual and semi‐automated cell counting performances were compared using validation parameters from ICH Q2(R1). Specificity, linearity, and repeatability served as key validation parameters in the evaluation of total cell density and cell viability of CHO‐K1 cells using trypan blue exclusion staining.
Selina Uhlendorff +3 more
wiley +1 more source
The Depositional Record, Volume 12, Issue 1, February 2026.Cluster‐based chemostratigraphy using XRF‐CS enables high‐resolution correlation of event deposits across contrasting depositional settings in the Japan Trench. This approach reveals previously unrecognised events and compositional heterogeneity, offering new insights into sediment provenance and earthquake‐triggered deposition, with implications for ...
Jyh‐Jaan Steven Huang +4 more
wiley +1 more source
Hematology, Transfusion and Cell TherapyCase Report: Systemic amyloidosis results from the production of misfolded immunoglobulin light chains by monoclonal CD38+ plasma cells. These misfolded light chains form amyloid fibrils, which accumulate in various tissues and cause organ damage ...
Metban Mastanzade +6 more
doaj +1 more source
Glia, Volume 74, Issue 2, February 2026.Prolactin action is essential for proper myelination of white matter tracts during neonatal and prepubertal stages in mice. Lack of prolactin receptor (Prlr−/−) signaling leads to hypomyelination and impaired locomotor function. ABSTRACT A large wave of myelination in the central nervous system (CNS) of mammals occurs during postnatal development ...
Ana L. Ocampo‐Ruiz +12 more
wiley +1 more source
Journal of Medical Virology, Volume 98, Issue 2, February 2026.ABSTRACT HTLV‐1 infection is a chronic condition associated with the development of malignancies, inflammatory, and neurological disorders. In this study, the causes of hospitalization and mortality were assessed in a cohort of 508 individuals living with HTLV‐1 followed over a 30‐year period. Overall mortality was 8.5% in this population and increased
Elizabeth Souza Neves +10 more
wiley +1 more source
AGU Advances, Volume 7, Issue 1, February 2026.Abstract In January 2025, wildfires caused catastrophic impacts to the infrastructure, communities, and environment of Los Angeles. This study documents the remotely sensed fire spread, intensity, and smoke emissions from the wildfires by leveraging fire and emission observations from multiple satellites.
Fangjun Li +4 more
wiley +1 more source
Journal of Geophysical Research: Atmospheres, Volume 131, Issue 2, 28 January 2026.Abstract Launched in April 2023, the Tropospheric Emissions: Monitoring of Pollution (TEMPO), instrument provides for the first time hourly measurements of atmospheric pollutants over most of North America at high spatial resolution (∼2 × 4.75 km2).
Prajjwal Rawat +17 more
wiley +1 more source