Results 21 to 30 of about 84,918 (116)

miR-340: A multifunctional role in human malignant diseases

International Journal on Biological Sciences, 2021
MicroRNAs (miRNAs) are a class of short non-coding RNAs of approximately 22 nucleotides in length, which function by binding to the 3' UTR sequences of their target mRNAs.
Zheng Huang, Yesha Xu, M. Wan, Xixi Zeng, Jianmin Wu   +4 more
semanticscholar   +1 more source

Soil microbial diversity and community composition during conversion from conventional to organic agriculture

Molecular Ecology, Volume 31, Issue 15, Page 4017-4030, August 2022., 2022
Abstract It is generally assumed that the dependence of conventional agriculture on artificial fertilizers and pesticides strongly impacts the environment, while organic agriculture relying more on microbial functioning may mitigate these impacts. However, it is not well known how microbial diversity and community composition change in conventionally ...
Sophie Q. van Rijssel, G. F. (Ciska) Veen, Guusje J. Koorneef, J. M. T. (Tanja) Bakx‐Schotman, Freddy C. ten Hooven, Stefan Geisen, Wim H. van der Putten   +6 more
wiley   +1 more source

MicroRNA-340 and MicroRNA-450b-5p: Plasma Biomarkers for Detection of Non-Small-Cell Lung Cancer

Journal of Environmental and Public Health, 2022
Objective Since the inefficient cancer management is caused by inaccurate diagnoses, there is a need for minimally invasive method to improve the diagnostic accuracy of non-small-cell lung (NSCLC).
Yanmin Wu, Hui Jing, Jinghao Zhang
semanticscholar   +1 more source

Autologous red blood cell transfusion does not result in a more profound increase in pulmonary capillary wedge pressure compared to saline in critically ill patients: A randomized crossover trial

Vox Sanguinis, Volume 117, Issue 8, Page 1035-1042, August 2022., 2022
Abstract Background and Objectives Transfusion‐associated circulatory overload (TACO) is a major cause of severe transfusion‐related morbidity. Transfusion of red blood cells (RBCs) has been shown to induce hydrostatic pressure overload. It is unclear which product‐specific factors contribute.
Joachim J. Bosboom, Robert B. Klanderman, Lotte E. Terwindt, Esther B. Bulle, Marije Wijnberge, Susanne Eberl, Antoine H. Driessen, Toon A. Winkelman, Bart F. Geerts, Denise P. Veelo, Markus W. Hollmann, Alexander P. J. Vlaar   +11 more
wiley   +1 more source

The MFF-SIRT1/3 axis, regulated by miR-340-5p, restores mitochondrial homeostasis of hypoxia-induced pulmonary artery smooth muscle cells

Laboratory Investigation, 2022
Mitochondrial dynamics and quality control play a central role in the maintenance of the proliferation–apoptosis balance, which is closely related to the progression of pulmonary arterial hypertension (PAH).
Chunmei Huang, Zhijing Jiang, Da-yong Du, Zhi-min Zhang, Yang Liu, Yun-Tian Li   +5 more
semanticscholar   +1 more source

Predictive metabolomics of multiple Atacama plant species unveils a core set of generic metabolites for extreme climate resilience

New Phytologist, Volume 234, Issue 5, Page 1614-1628, June 2022., 2022
Summary Current crop yield of the best ideotypes is stagnating and threatened by climate change. In this scenario, understanding wild plant adaptations in extreme ecosystems offers an opportunity to learn about new mechanisms for resilience. Previous studies have shown species specificity for metabolites involved in plant adaptation to harsh ...
Thomas Dussarrat, Sylvain Prigent, Claudio Latorre, Stéphane Bernillon, Amélie Flandin, Francisca P. Díaz, Cédric Cassan, Pierre Van Delft, Daniel Jacob, Kranthi Varala, Jérôme Joubes, Yves Gibon, Dominique Rolin, Rodrigo A. Gutiérrez, Pierre Pétriacq   +14 more
wiley   +1 more source

Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis

Bioengineered, 2021
As a malignant disease, lung cancer has a high morbidity and mortality rate. Baicalin is derived from Radix Scutellariae and has anti-tumor effects, however, its role in lung cancer remains unknown.
Fucheng Zhao, Zhenxia Zhao, Yanru Han, Sujuan Li, Caili Liu, Kui Jia   +5 more
semanticscholar   +1 more source

LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway

Journal of experimental & clinical cancer research : CR, 2020
LncRNA LINC00662 is closely related to the occurrence and development of cancer. This study aims to explore the effect of LINC00662 on colon cancer tumor growth and metastasis and its molecular mechanism. CCK8, colony formation, transwell, scratch wound,
B. Cheng, Aimei Rong, Quanbo Zhou, Wenlu Li   +3 more
semanticscholar   +1 more source

NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation

RNA Biology, 2021
NEDD4 is an E3 ubiquitin ligase that recognizes substrates through protein–protein interactions and is involved in cancer development. This study aimed to elucidate the function of NEDD4 in colon cancer (CC) progression and its mechanism of action. NEDD4
Meng Yue, Zhennan Yun, Shiquan Li, Guoqiang Yan, Zhenhua Kang   +4 more
semanticscholar   +1 more source

Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10

Journal of experimental & clinical cancer research : CR, 2020
Background Radiotherapy resistance is a major obstacle in the treatment of oesophageal squamous cell carcinoma (OSCC). Hypoxia is a critical cause of radioresistance.
Fangyu Chen, Bing Xu, Jie Li, Xi Yang, J. Gu, Xijuan Yao, Xinchen Sun   +6 more
semanticscholar   +1 more source