Results 91 to 100 of about 3,198,629 (233)

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer’s disease

Nature Communications
Understanding why certain neurons are more sensitive to dysfunction and death caused by misfolded proteins could provide therapeutically relevant insights into neurodegenerative disorders.
Jessy A. Slota, Lise Lamoureux, Kathy L. Frost, Babu V. Sajesh, Stephanie A. Booth   +4 more
doaj   +1 more source

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

NEVBD Quarterly Digest Issue 8

, 2020
The Northeast Regional Center for Excellence in Vector-Borne Diseases (NEVBD) issues a quarterly digest featuring articles on the latest NEVBD-sponsored research programs, training events, and highlights of our regional partners.The Northeast Regional ...
Northeast Regional Center for Excellence in Vector-Borne Diseases
core   +1 more source

Vector-Borne and Zoonotic Diseases in Dogs and Cats

Vector-borne and zoonotic diseases in dogs and cats are widely distributed throughout the world; however, their epidemiology and etiology varies depending on the specific climatic conditions, as well as the presence and abundance of vectorial agents ...

core   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Study on the aggregation patterns of fleas parasitizing the great gerbil (Rhombomys opimus) in the Junggar Basin plague natural focus

Parasites & Vectors
Background The great gerbil (Rhombomys opimus), whose ectoparasitic fleas significantly influence the transmission and prevalence of plague, was the dominant rodent species in the Junggar Basin in Northwestern China.
Fang Li, Guoyu Zhao, Yu Wang, Shang Zhan, Xine Tang, Tao Luo, Abulimiti Moming, Huiqian Wang, Jianhui Chen, Qiguo Wang, Haiyan Wu, Yujiang Zhang   +11 more
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Evaluation of the safety and insecticidal efficacy of ivermectin-treated bird feed formulations in different avian species

Parasites & Vectors
Background West Nile virus (WNV) is maintained in an enzootic cycle between reservoir host birds and Culex (Cx.) spp. mosquitoes. This relationship presents a potential target for vector control strategies.
Michelle J. Savran, Kathryn Coffin, Claire M. Stewart, Chilinh Nguyen, Catalina Puska, Molly E. Ring, Anna-Sophia Leon, Preston Schweiner, Tilman Peters, Jenna C. Randall, Jenny Buczek, Paula Lado, Emily N. Gallichotte, Brady Clapsaddle, Christopher M. Barker, Gregory D. Ebel, Brian D. Foy   +16 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source