Results 31 to 40 of about 1,674,962 (266)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Microbiome diversity in mosquitoes and sand flies: implications for vector competence

Parasites & Vectors
Mosquitoes and sand flies are the most important vectors of several human diseases. A comprehensive analysis of the diversity and composition of the microbiome in mosquitoes and sandflies is important.
Gnanasekar Ragini, Mahima K. Mani, Rohit Sharma, Nikhil Bharadwaj, Muthukumaravel Subramanian, Shriram Ananganallur Nagarajan, Manju Rahi   +6 more
doaj   +1 more source

Migratory birds have a distinct haemosporidian community and are temporally decoupled from vector abundance at a stopover site

Parasitology
Migratory animals likely play an important role in the geographic spread of parasites. In fact, a common assumption is that parasites are potentially transmitted by migratory animals at temporary stopover sites along migratory routes, yet very few ...
Spencer C. Galen, Emily Ostrow, Suravi Ray, Marissa Henry, Janice Dispoto, Alison Fetterman, Lisa Kiziuk, Jason D. Weckstein   +7 more
doaj   +1 more source

Establishment of a Simple and Efficient Reverse Genetics System for Canine Adenoviruses Using Bacterial Artificial Chromosomes

Viruses, 2020
Canine adenoviruses (CAdVs) are divided into pathotypes CAdV1 and CAdV2, which cause infectious hepatitis and laryngotracheitis in canid animals, respectively.
Hiromichi Matsugo, Tomoya Kobayashi-Kitamura, Haruhiko Kamiki, Hiroho Ishida, Akiko Takenaka-Uema, Shin Murakami, Taisuke Horimoto   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Evaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control

Scientific Reports
Vector control is a key intervention against mosquito borne diseases. However, conventional methods have several limitations and alternate strategies are in urgent need. Vector control with endectocides such as ivermectin is emerging as a novel strategy.
Harish Kumar Shah, Vaishnavi Srinivasan, Shakila Venkatesan, Vijayakumar Balakrishnan, Sadanandane Candasamy, Nisha Mathew, Ashwani Kumar, Vijesh Sreedhar Kuttiatt   +7 more
doaj   +1 more source

Temporal-Microclimatic Factors Affect the Phenology of Lipoptena fortisetosa in Central European Forests

Animals, 2020
The objective of this study was to determine the correlations between the abundance of Lipoptena fortisetosa on new potential hosts and selected temporal-microclimatic conditions in a forest at the beginning of the host-seeking period.
Remigiusz Gałęcki, Jerzy Jaroszewski, Xuenan Xuan, Tadeusz Bakuła   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Seasonal dynamics and species diversity of Anopheles mosquitoes in malaria endemic districts of Southern Odisha India

Scientific Reports
Mosquitoes of the Anopheles, Aedes, and Culex genera are responsible for transmitting major vector-borne diseases. Malaria remains a significant public health concern in Odisha, primarily due to the state’s conducive environment for Anopheles mosquito ...
Muhammed Mustafa Baig, Divya Teja Koppula, Dilip Kumar Panigrahi, B. Vijayakumar, Dolly Choudhary, Premalatha Acharya, Manoj Patnaik, K. Gunasekaran, Ashwani Kumar, Manju Rahi, A. N. Shriram   +10 more
doaj   +1 more source

DNA Vaccines: Their Formulations, Engineering and Delivery

Vaccines
The concept of DNA vaccination was introduced in the early 1990s. Since then, advancements in the augmentation of the immunogenicity of DNA vaccines have brought this technology to the market, especially in veterinary medicine, to prevent many diseases ...
Michael Kozak, Jiafen Hu
doaj   +1 more source