Results 121 to 130 of about 25,848,277 (298)

Benchmarking least squares support vector machine classifiers. [PDF]

In Support Vector Machines (SVMs), the solution of the classification problem is characterized by a ( convex) quadratic programming (QP) problem. In a modified version of SVMs, called Least Squares SVM classifiers (LS-SVMs), a least squares cost function
Suykens, Johan, Vandewalle, Joos, De Moor, Bart, Van Gestel, Tony, Vanthienen, Jan, Baesens, Bart, Dedene, Guido, Viaene, Stijn   +7 more
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Imported dengue fever in South Korea, 2020–2024: Epidemiological trends and serotype distribution from national laboratory surveillance

Travel Medicine and Infectious Disease
Background: South Korea remains at risk for dengue virus (DENV) importation, primarily due to the widespread presence of Aedes albopictus and increasing international travel.
Ye-Ji Lee, Seung-Rye Cho, Won Kyong Kim, Myung Guk Han, Seon-Young Lee, So-dam Lee, Jonghee Kim, Heui Man Kim   +7 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Efficacy of Interceptor G2, Royal Guard and PermaNet 3.0 against pyrethroid-resistant Anopheles gambiae s.l. from Za-Kpota, southern Benin: an experimental hut trial

Parasites & Vectors
Background The widespread use of insecticide-treated nets (ITNs) has significantly contributed to the reduction in malaria cases and deaths observed across Africa.
Pierre Marie Sovegnon, Romaric Akoton, Isaac J. Stopard, Thomas S. Churcher, Philip J. McCall, Hilary Ranson, Geraldine M. Foster, Luc Salako Djogbénou   +7 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

House modifications using insecticide-treated screening of eave and window as a vector control tool: evidence from a semi-field system in Tanzania and simulated epidemiological impact

BMC Public Health
Background Gaps in unimproved house structures, especially in eaves and windows, allow mosquito entry, increasing indoor vector-borne disease transmission.
Olukayode G. Odufuwa, Richard J. Sheppard, Safina Ngonyani, Ahmadi Bakari Mpelepele, Dickson Kobe, Agathus Njohole, Jason Moore, Jastin Lusoli Lusoli, Joseph B. Muganga, Rune Bosselmann, Ole Skovmand, Zawadi Mageni Mboma, Emmanuel Mbuba, Rose Philipo, Jennifer C Stevenson, Ellie Sherrard-Smith, John Bradley, Sarah Jane Moore   +17 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A goatpox but not sheeppox heterologous live attenuated vaccines provide complete protection against lumpy skin disease in cattle under experimental conditions

Scientific Reports
Homologous vaccination has proven to be an effective tool to control and eradicate lumpy skin disease. However, their use has been met with some trepidation for diverse reasons, in some regions, and has resulted in the use of heterologous vaccines ...
Andy Haegeman, Wannes Philips, Laurent Mostin, Ilse De Leeuw, Willem Van Campe, Claude Saegerman, Kris De Clercq, Nick De Regge   +7 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source