Results 81 to 90 of about 25,848,277 (298)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction

Frontiers in Cell and Developmental Biology
ObjectiveThe aim of this study was to conduct a systematic investigation into the effects of ocular rotation on postoperative residual astigmatism in patients undergoing small incision lenticule extraction (SMILE).MethodsA prospective observational ...
Caiyu Liu, Caiyu Liu, Xiaoying Xu, Xiaoying Xu, Xiaoying Xu, Hao Gu, Hao Gu, Hao Gu, Chi Wang, Chi Wang, Lu Lu, Lu Lu, Kaizhen Ye, Kaizhen Ye, Yan Zheng, Yan Zheng, Haiyan Wang, Wei Chen, Meiyan Li, Xiaolin Zhou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Shangkun Ou, Fangwen Yang, Fangwen Yang   +25 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Refractive and Vector Outcomes of SMILE Pro with the VISUMAX 800 for High Astigmatism

Vision
Background/Objectives: High astigmatism remains challenging in keratorefractive lenticule extraction because small errors in centration or cyclotorsion may affect astigmatic correction. This study evaluated early refractive and astigmatic vector outcomes
Lan Huong Thi Tran, Thanh Ngoc Tran, Hong Son Cung, Khanh-Sam Tran, Van Trong Pham   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Within-Season Ecoenzymatic Responses to Cover Cropping in a Subtropical Agroecosystem

Soil Systems
Ecoenzymatic stoichiometry links extracellular enzyme allocation to microbial resource-acquisition patterns, yet its behavior in managed subtropical soils remains poorly resolved.
Hamed Arfania, Tanjila Jesmin, Noel Manirakiza, Suraj Melkani, Jay Capasso, Hardeep Singh, Berson J. Valcin, Kevin Korus, Abul Rabbany, Tamara Serrano, Zachary Brym, Jehangir H. Bhadha   +11 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Impact of corneal cross-linking combined with photorefractive keratectomy on blurring strength

Clinical Ophthalmology, 2016
Georgios Labiris,1,2 Haris Sideroudi,2 Dimitris Angelonias,2 Kimonas Georgantzoglou,2 Vassilios P Kozobolis1,21Department of Ophthalmology, University Hospital of Alexandroupolis, 2Eye Institute of Thrace, Alexandroupolis, GreecePurpose: The aim of this ...
Labiris G, Sideroudi H, Angelonias D, Georgantzoglou K, Kozobolis VP   +4 more
doaj  

Exploring the association between bioelectrical impedance parameters and body composition in women with and without dysmenorrhea and postmenopause

Physiological Reports
Female reproductive status influences body composition, including fat mass (FM), fat‐free mass (FFM), and bone health. We aimed to examine differences in body composition, bone health, and bioelectrical impedance analysis (BIA) parameters, including ...
Suraiya Khatun, Akiko Uchizawa, Emi Kondo, Analiza M. Silva, Yuki Shimamura, Shogo Yamasaki, Yuki Ahagon, Daisuke Hoshi, Yoshiaki Tanaka, Naoki Mukai, Koichi Watanabe, Naomi Omi, Kiyoji Tanaka, Hiroyuki Sagayama   +13 more
doaj   +1 more source