Results 291 to 300 of about 217,155 (332)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Para-Hisian Ventricular Arrhythmias: Beyond the Proximity to His Bundle. [PDF]

JACC Asia
Maruyama M.
europepmc   +1 more source

Evaluation of improved cassava genotypes for fresh root yield and yield components in demand creation trial. [PDF]

Front Plant Sci
Onyenali TC, Ogwuche TO, Onyeka J, Diebiru-Ojo EM, Ikechukwu I, Abah SP, Okwuonu I, Ameh EA, Sanni L, Kulakow AP, Egesi CN.   +10 more
europepmc   +1 more source

Identification and analysis of driving factors for ecosystem service bundles in Shanxi Province under multiple scenario simulations. [PDF]

Sci Rep
Dang G, Li G, Hu J.
europepmc   +1 more source

Septal-to-basal ventricular peak activation time determined by vectorcardiography as a potential new pre-screening parameter for preclinical dilated cardiomyopathy in Doberman Pinschers. [PDF]

Front Vet Sci
Gheeraert M, Wess G, Mampaey G, Eberhard J, Gheeraert P, De Pooter J, Duchateau L, Smets P.   +7 more
europepmc   +1 more source

Computational Model of the Effective Thermal Conductivity of a Bundle of Round Steel Bars. [PDF]

Materials (Basel)
Wyczółkowski R, Gała M.
europepmc   +1 more source

Left atrioventricular accessory pathway with Mahaim fiber characteristics: a rare case report. [PDF]

BMC Cardiovasc Disord
Han J, Yuan R, Li J, Wei Z, Chang P.
europepmc   +1 more source