Results 41 to 50 of about 221,316 (324)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Моделирование и анализ информационных систем, 2015 A linear projective ind-variety X is called 1-connected if any two points on it can be connected by a chain of lines l1, l2, ..., lk in X, such that li intersects li+1.
S. M. Yermakova
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A note on Demailly’s approach towards a conjecture of Griffiths
Comptes Rendus. Mathématique, 2021 We prove that a “cushioned” Hermitian–Einstein-type equation proposed by Demailly in an approach towards a conjecture of Griffiths on the existence of a Griffiths positively curved metric on a Hartshorne ample vector bundle, has an essentially unique ...
Pingali, Vamsi Pritham
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Lifting vector bundles to Witt vector bundles
Israel Journal of MathematicsLet $X$ be a scheme. Let $r \geq 2$ be an integer. Denote by $W_r(X)$ the scheme of Witt vectors of length $r$, built out of $X$. We are concerned with the question of extending (=lifting) vector bundles on $X$, to vector bundles on $W_r(X)$-promoting a systematic use of Witt modules and Witt vector bundles. To begin with, we investigate two elementary
De Clercq, Charles +2 more
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Can You Hear the Shape of a Market? Geometric Arbitrage and Spectral Theory
Axioms, 2021 Utilizing gauge symmetries, the Geometric Arbitrage Theory reformulates any asset model, allowing for arbitrage by means of a stochastic principal fibre bundle with a connection whose curvature measures the “instantaneous arbitrage capability”.
Simone Farinelli, Hideyuki Takada
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Vector bundles on rational homogeneous spaces [PDF]
, 2021 Rong Du, Xinyi Fang, Yun Gao
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Higher order jet prolongations type gauge natural bundles over vector bundles
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2004 Let $rgeq 3$ and $mgeq 2$ be natural numbers and $E$ be a vector bundle with $m$-dimensional basis. We find all gauge natural bundles ``similar" to the $r$-jet prolongation bundle $J^rE$ of $E$.
Jan Kurek, Włodzimierz M. Mikulski
doaj