Results 41 to 50 of about 223,260 (263)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Higher order jet prolongations type gauge natural bundles over vector bundles

open access: yesAnnales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2004
Let $rgeq 3$ and $mgeq 2$ be natural numbers and $E$ be a vector bundle with $m$-dimensional basis. We find all gauge natural bundles ``similar" to the $r$-jet prolongation bundle $J^rE$ of $E$.
Jan Kurek, Włodzimierz M. Mikulski
doaj  

Fiber-Preserving Conformal Vector Field of Frame Bundles with Natural Riemannian Metric [PDF]

open access: yesMemoirs of the Scientific Sections of the Romanian Academy, 2019
We consider the bundle of all oriented orthonormal frames over an orientable Remannian manifold. This bundle has a natural Riemannian metric which is defined by the Riemannian connection of the base manifold.
M.T.K. Abbassi , N. Amri
doaj  

Brill-Noether-general limit root bundles: absence of vector-like exotics in F-theory Standard Models

open access: yesJournal of High Energy Physics, 2022
Root bundles appear prominently in studies of vector-like spectra of 4d F-theory compactifications. Of particular importance to phenomenology are the Quadrillion F-theory Standard Models (F-theory QSMs).
Martin Bies   +3 more
doaj   +1 more source

Can You Hear the Shape of a Market? Geometric Arbitrage and Spectral Theory

open access: yesAxioms, 2021
Utilizing gauge symmetries, the Geometric Arbitrage Theory reformulates any asset model, allowing for arbitrage by means of a stochastic principal fibre bundle with a connection whose curvature measures the “instantaneous arbitrage capability”.
Simone Farinelli, Hideyuki Takada
doaj   +1 more source

Real Hypersurfaces of Type A in Complex Two-Plane Grassmannians Related to The Reeb Vector Field

open access: yes, 2015
Y. J. Suh and H. Lee (Bull. Korean. Math. Soc. 47, 551-561 (2010)) characterized real hypersurfaces $M$ of type $B$ by the invariance of vector bundle $JTM^\perp$ under the shape operator and the orthogonality of $JTM^\perp$ and $\mathcal {J}TM^\perp ...
Lee, Ruenn-Huah, Loo, Tee-How
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Approximation and extension of Hermitian metrics on holomorphic vector bundles over Stein manifolds

open access: yesComptes Rendus. Mathématique
We show that a singular Hermitian metric on a holomorphic vector bundle over a Stein manifold which is negative in the sense of Griffiths (resp. Nakano) can be approximated by a sequence of smooth Hermitian metrics with the same curvature negativity.
Deng, Fusheng   +3 more
doaj   +1 more source

Polystable bundles and representations of their automorphisms

open access: yesComplex Manifolds, 2022
Using a quasi-linear version of Hodge theory, holomorphic vector bundles in a neighbourhood of a given polystable bundle on a compact Kähler manifold are shown to be (poly)stable if and only if their corresponding classes are (poly)stable in the sense of
Buchdahl Nicholas, Schumacher Georg
doaj   +1 more source

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