Results 51 to 60 of about 223,260 (263)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

ON THE LIFTS OF SEMI-RIEMANNIAN METRICS [PDF]

Journal of Sciences, Islamic Republic of Iran, 1994
In this paper, we extend Sasaki metric for tangent bundle of a Riemannian manifold and Sasaki-Mok metric for the frame bundle of a Riemannian manifold [I] to the case of a semi-Riemannian vector bundle over a semi- Riemannian manifold. In fact, if E is a
doaj  

On the scalar components of the canonical form on higher order frame bundles

Дифференциальная геометрия многообразий фигур
A detailed obtaining of the expressions for the scalar components of the canonical form on higher order frame bundles over a smooth manifold has been done.
A. V. Kuleshov
doaj   +1 more source

Weighted E-Spaces and Epistemic Information Operators

Information, 2014
Information is usually related to knowledge. Here, we present a broader picture in which information is associated with epistemic structures, which form cognitive infological systems as basic recipients and creators of cognitive information.
Mark Burgin
doaj   +1 more source

Vector bundles of rank four and A_3 = D_3

, 2012
Over a scheme with 2 invertible, we show that a vector bundle of rank four has a sub or quotient line bundle if and only if the canonical symmetric bilinear form on its exterior square has a lagrangian subspace.
Asher Auel, Atiyah, Balmer, Balmer, Balmer, Balmer, Balmer, Bichsel, Bourbaki, Bruns, Calmès, Demazure, Demazure, Elman, Fasel, Fasel, Fasel, Fasel, Fulton, Gille, Grothendieck, Hartshorne, Hassett, Knebusch, Knus, Knus, Milne, Morel, Mumford, Parimala, Quebbemann, Quebbemann, Roy   +32 more
core   +1 more source

Anti-ample bundle, nef vector bundle, big vector bundle

7 pages.
Biswas, Indranil, Laytimi, Fatima, Nagaraj, D. S., Nahm, Werner   +3 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Vector Bundles and F Theory [PDF]

Communications in Mathematical Physics, 1997
93 pp., harvmac. Section 4.4 has been extended with additional Comments relating F theory intermediate Jacobians to heterotic string ...
Friedman, Robert, Morgan, John, Witten, Edward   +2 more
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source