Results 31 to 40 of about 15,996,300 (248)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Threshold Effects in Multivariate Error Correction Models [PDF]

, 2006
We propose a testing procedure for assessing the presence of threshold effects in nonstationary vector autoregressive models with or without cointegration.
Gonzalo, Jesús, Pitarakis, Jean-Yves
core   +1 more source

Does The Price Puzzle Exist in Colombia? Empirical Evidence and Policy Implications

Ecos de Economía, 2006
The price puzzle has been the focus of many studies, however, most of these studies have focused on developed economies and especially on the U.S. Owing to this tendency; we do not know if there is existence of a price puzzle in developing economies ...
Blen Solomon, Isabel Ruiz
doaj  

VECTOR ERROR CORRECTION MODEL FOR FORECASTING SHEEP NUMBERS IN BULGARIA [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2016
The aim of this study was to forecast sheep numbers in Bulgaria on 01.11.2016 and on 01.11.2017, using a vector error correction model (VECM). A vector error correction model was constructed to forecast sheep numbers in Bulgaria for 2016 and 2017.
Tsvetana HARIZANOVA–METODIEVA, Hristina HARIZANOVA, Zornica STOYANOVA   +2 more
doaj  

A Vector Error Correction Model to Estimate Potato Supply Response in Colombia

Ciencia y Tecnología Agropecuaria, 2022
The present study aims to investigate the relationship between potato output supply and potato and fertilizer prices in Colombia using 2003-2018 time series data.
Giovanni Orlando Cancino Escalante, Susan Elsa Cancino, Daniel Francisco Cancino Ricketts   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prediksi Spot Price Komoditas Emas Berjangka dengan Pendekatan Vector Error Correction Model

Jambura Journal of Mathematics, 2023
Time series data usually exhibit non-stationary behavior and involve interrelated variables. Thus, we need a model that can obtain good forecasting results from non-stationary time series data with multivariate variables.
Izma Fahria, Desy Yuliana Dalimunthe, Ririn Amelia, Ineu Sulistiana, Baiq Desy Aniska Prayanti   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source