Results 41 to 50 of about 577,678 (259)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Diversity and spatiotemporal distribution of mosquitoes (Diptera: Culicidae) with emphasis on disease vectors across agroecological areas of Kerala, India

Scientific Reports
Mosquitoes are important vectors of several diseases that significantly impact public health globally. This multi-district mosquito survey revealed the diversity and distribution of mosquito species across varied agroecological areas in Kerala, India ...
L. Mathiarasan, R. Natarajan, A. Aswin, N. A. Johnson Amala Justin, Nivetha Thampi, Manisha Kumari, G. Sri Lakshmi Priya, P. D. Rohini, S. Gopalakrishnan, P. Jambulingam, Alex Eapen   +10 more
doaj   +1 more source

Age and sex distribution trends of SARS-CoV-2 infections: Insights from three epidemic waves in Puducherry, India

Journal of Infection in Developing Countries
Introduction: This study analyzed the age and sex distribution of COVID-19 patients during the initial three COVID-19 waves in Puducherry, India, from August 2020 to March 2022, to understand the distribution of infection across different demographic ...
Lourduraj John De Britto, Arya Rahul, Dinesh Sundaram, Balakrishnan Vijayakumar, Thirumal Sankari, Muthukumaravel Subramanian, Raja Jeyapal Dinesh, Philip Raj Abraham, Panneer Devaraju, Yasin Nazeer, Ayyanar Elango, Balasubramaniyan Ramalingam, Kulandaisamy Athisaya Mary, Suchi Tyagi, Rituraj Niranjan, Paramasivan Rajaiah, Mayilsamy Muniaraj, Narendran Pradeep Kumar, Irudayaraj Geetha, Ananganallur Nagarajan Shriram, Adinarayanan Srividya, Vijesh Sreedhar Kuttiatt, Ashwani Kumar   +22 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Genome resequencing and genome-wide polymorphisms in mosquito vectors Aedes aegypti and Aedes albopictus from south India

Scientific Reports
Aedes aegypti and Aedes albopictus mosquitoes spread major vector-borne viral diseases in tropical and sub-tropical regions of the globe. In this study, we sequenced the genome of Indian Ae. aegypti and Ae.
Preeti Acharya, Upasana Shyamsunder Singh, Veeramanoharan Rajamannar, Mayilsamy Muniaraj, Binata Nayak, Aparup Das   +5 more
doaj   +1 more source

Comparative Analysis of Phlebotomus argentipes Vector of Leishmaniasis in India and Sri Lanka

Microorganisms
Phlebotomus argentipes is the predominant sandfly vector of leishmaniasis in the Indian subcontinent. India and Sri Lanka primarily report visceral and cutaneous leishmaniasis caused by Leishmania donovani. We compared Ph.
Sachee Bhanu Piyasiri, P.A. Fathima, Harish Kumar Shah, Sanath Senanyake, Nilakshi Samaranayake, Nadira Darshani Karunaweera, Manju Rahi, Prasanta Saini   +7 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Malaria and missed school days: exploring school absenteeism patterns and local strategies in Odisha, India

Frontiers in Public Health
BackgroundMalaria continues to pose a significant global health challenge, disproportionately affecting children. While its effects on physical health are well-documented, the impact on education, particularly school absenteeism, remains less understood.
Muhammed Jabir, Dilip K. Panigrahi, Muhammad M. Baig, Vijayakumar Balakrishnan, Prasant K. Panda, Ashwani Kumar, Manju Rahi, Ananganallur N. Shriram   +7 more
doaj   +1 more source

Adverse moisture events predict seasonal abundance of Lyme disease vector ticks (Ixodes scapularis)

Parasites & Vectors, 2014
Background Lyme borreliosis (LB) is the most commonly reported vector-borne disease in north temperate regions worldwide, affecting an estimated 300,000 people annually in the United States alone.
Kathryn A Berger, Howard S Ginsberg, Katherine D Dugas, Lutz H Hamel, Thomas N Mather   +4 more
doaj   +1 more source