Results 61 to 70 of about 712,718 (291)

Fitness and freezing: vector biology and human health [PDF]

Journal of Clinical Investigation, 2010
Microbes transmitted to mammals by arthropods contend with many factors that could impede survival. To survive, host fitness with infection must outweigh costs. In this issue of the JCI, Neelakanta et al. demonstrate that ticks infected with Anaplasma phagocytophilum show enhanced fitness against freezing injury owing to induced expression of tick ...
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Application of Extrapolation Capability of Vector Fitting for Out-of-Band Dominant Modal Synthesis of Voltage-Source Converters

IEEE Open Access Journal of Power and Energy
Conventional state-space-based stability assessment method of voltage-source converters (VSCs) can be hindered by the black-box feature. Black box-based state-space model identification method using the terminal admittance/impedance frequency responses ...
Weihua Zhou, Jef Beerten
doaj   +1 more source

Vector Fitting

, 2019
This work is a draft of the book chapter P. Triverio, "Vector Fitting" that will be part of the "Handbook on Model Order Reduction" edited by P. Benner, S. Grivet-Talocia, A. Quarteroni, G. Rozza, W. H. A. Schilders, L. M.
openaire   +2 more sources

data fitting by vector (V,f)-reproducing kernels [PDF]

ESAIM: Proceedings, 2007
In this paper we propose a constructive method to build vector reproducing kernels. We deflne the notion of vector (V,f)-reproducing kernel and we prove that every vector reproducing kernel is a (V,f)-reproducing kernel. We study the minimal approximation by these (V,f)-reproducing kernels for difierent choices of V and f. Resume.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Applying machine learning to the problem of choosing a heuristic to select the variable ordering for cylindrical algebraic decomposition [PDF]

, 2014
Cylindrical algebraic decomposition(CAD) is a key tool in computational algebraic geometry, particularly for quantifier elimination over real-closed fields. When using CAD, there is often a choice for the ordering placed on the variables.
A. Dolzmann, A. Strzeboński, B. Akbarpour, C. Brown, C. Brown, C. Brown, D. Arnon, D. Jovanović, D. Wilson, F. Rosenblatt, F. Sebastiani, G. Collins, G.E. Collins, K. Hornik, P. Baldi, P. Stone, R. Bradford, W.S. McCulloch   +17 more
core   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Data-Driven Modeling of Weakly Nonlinear Circuits via Generalized Transfer Function Approximation

IEEE Access
This paper presents an extension of the Vector Fitting algorithm with the purpose of constructing compact behavioral models of weakly nonlinear circuits starting from frequency-domain input-output data.
Antonio Carlucci, Ion Victor Gosea, Stefano Grivet-Talocia   +2 more
doaj   +1 more source