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, 2011 Contents: Letter from the Editors -- Science Fiction or Science Face? -- More Social, More Connected -- The Audience's New Groove -- Feel the Drama -- The Future of Engineering -- Knowing Unclear -- Utopia or Not -- VectortainmentVector is the ...
University of Texas at Austin
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On Perturbation Measure for Binary Vectors [PDF]
, 2015 The paper is about remoteness of objects described by the nominal-valued attributes. Nominal values of the attributes are replaced by respective binary vectors. A new measure of remoteness between sets, based on binary attributes’ values, is introduced.
Maciej Krawczak, Grazyna Szkatula
openaire +2 more sources
Vector Quantization of Images Using the
, 1995 This paper considers the vector quantization of signals using the L1 distortion measure. The key contribution is a result that allows one to characterize the centroid of a set of vectors for the L1 distortion measure.
Distortion Measure +2 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ON THE MEASURE INDUCED BY THE VECTOR VALUED MEASURE
, 1974 We shall study for real valued measure induced by the vector valued measure. Vector measure means a set function m defined on a-ring S with values in vector space Y has the following properties; ⅰ) m(Φ)=0 ( 0 is the zero vector in Y ) ⅱ) For every ...
이상련
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, 2011 Vector is the student engineering magazine on campus. Published by the Student Engineering Council, Vector is completely written, managed, and designed by students for students.
University of Texas at Austin
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source