Results 121 to 130 of about 600,320 (348)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

BOOL-AN: A method for comparative sequence analysis and phylogenetic reconstruction [PDF]

, 2009
A novel discrete mathematical approach is proposed as an additional tool for molecular systematics which does not require prior statistical assumptions concerning the evolutionary process.
Ittzés, Péter, Jakó, Éena, Horváth, Arnold, Podani, János, Ari, Eszter   +4 more
core   +1 more source

Malaria and Lyme disease - the largest vector-borne US epidemics in the last 100 years: success and failure of public health

BMC Public Health, 2019
Malaria and Lyme disease were the largest vector-borne epidemics in recent US history. Malaria, a mosquito-borne disease with intense transmission, had higher morbidity and mortality, whereas Lyme and other tick-borne diseases are more persistent in the ...
Ilia Rochlin, Dominick V. Ninivaggi, Jorge L. Benach   +2 more
doaj   +1 more source

Bridging the gaps in vector biology [PDF]

EMBO reports, 2006
David S, Schneider, Anthony A, James
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Discovery of new antigens for serodiagnosis of visceral leishmaniasis in humans and dogs adds valuable tools to our arsenal

mBio
Surveillance and sustained control of visceral leishmaniasis (VL) require reliable serodiagnostic tools. rK39, the gold standard antigen for VL diagnosis, is limited by its documented poor sensitivity in certain endemic regions, such as East Africa, and ...
Eva Iniguez, Shaden Kamhawi
doaj   +1 more source

Molecular innovations in medical entomology for targeting vector biology and viral pathogenesis in dengue control

Discover Viruses
Abstract Dengue virus affects millions of people annually, particularly in tropical and subtropical regions where Aedes mosquitoes serve as primary vectors. Conventional control measures face limitations due to pesticide resistance, environmental concerns, and issues of host
Aroni Preya Biswas, Anika Yesmin Sorna, Md. Mamunur Rahman   +2 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comparison of various expression plasmids for the induction of immune response by DNA immunization

, 2019
Intramuscular injection of plasmid DNA is an efficient method to introduce a foreign gene into a Live animal. We investigated several factors affecting the gene transfer efficiency and the following immune response by intramuscular injection of plasmid ...
Yang, SH, Lee, AH, Sung, JH, Sung, YC, Suh, YS   +4 more
core  

Salivary gland proteins of the human malaria vector, Anopheles dirus B (Diptera Culicidae) [PDF]

, 2007
Salivary gland proteins of the human malaria vector, Anopheles dirus B were determined and analyzed. The amount of salivary gland proteins in mosquitoes aged between 3--10 days was approximately 1.08 +/- 0.04 microg/female and 0.1 +/- 0.05 microg/male ...
Mark C. Wilkinson, Bates, Paul A., Thasaneeya Harnnoi, Choochote, Wej, Anuluck Junkum, Wilkinson, Mark, Wilkinson, Mark C, Paul A. Bates, Wej Choochote, Siriyasatein, Padet, Atchariya Jitpakdi, Padet Siriyasatein, Harnnoi, Thasaneeya, Narissara Jariyapan, Jariyapan, Narissara, Bates, Paul A, Junkum, Anuluck, Jitpakdi, Atchariya   +17 more
core   +1 more source