Results 71 to 80 of about 1,209,062 (262)

Culex pipiens quinquefasciatus: a potential vector to transmit Zika virus

Emerging Microbes and Infections, 2016
Zika virus (ZIKV) has become a threat to global health since the outbreak in Brazil in 2015. Although ZIKV is generally considered an Aedes-transmitted pathogen, new evidence has shown that parts of the virus closely resemble Culex-transmitted viruses ...
Xiao-xia Guo, Chun-xiao Li, Yong-qiang Deng, Dan Xing, Qin-mei Liu, Qun Wu, Ai-juan Sun, Yan-de Dong, Wu-chun Cao, Cheng-feng Qin, Tong-yan Zhao   +10 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Controlling Andreev Bound States with the Magnetic Vector Potential. [PDF]

Nano Lett, 2022
Moehle CM, Rout PK, Jainandunsing NA, Kuiri D, Ke CT, Xiao D, Thomas C, Manfra MJ, Nowak MP, Goswami S.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Vector potential dual effect of promoting the proliferation of chondrocytes and inhibiting the calcification process in the articular cartilage. [PDF]

Sci Rep, 2023
Suito H, Minamizono W, Yashima N, Matsunaga H, Fujikawa K, Ohsako M.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The biotechnological potential of proteases from hematophagous arthropod vectors

Frontiers in Cellular and Infection Microbiology, 2023
Carla Nunes de Araújo, Carla Nunes de Araújo, Paula Beatriz Santiago, Giulia Causin Vieira, Gabriel dos Santos Silva, Renan Pereira Moura, Izabela Marques Dourado Bastos, Jaime Martins de Santana   +7 more
doaj   +1 more source

Ornithodoros kalahariensis, a potential vector for Candidatus Borrelia kalaharica

Ticks and Tick-Borne Diseases
Candidatus Borrelia kalaharica was proposed as bacterial species in 2016 using DNA extracted from a traveller returning from Southern Africa. We investigated DNA of three soft ticks collected in the Kalahari Game Reserve near Maun, Botswana via PCR.
Volker Fingerle, Heidelore Hofmann, Christine Hartberger, Gabriele Margos   +3 more
doaj   +1 more source

Intrinsic chiral field as vector potential of the magnetic current in the zig-zag lattice of magnetic dipoles. [PDF]

Sci Rep, 2023
Mellado P, Concha A, Hofhuis K, Tapia I.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source