Results 31 to 40 of about 413,476 (255)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Information retrieval algorithm of industrial cluster based on vector space

Open Physics, 2019
The current information retrieval research on industrial clusters has low precision, low recall ratio, obvious delay and high energy consumption. Thus, in this paper, a information retrieval algorithm based on vector space for industrial clusters is ...
Li Rongsheng, Hassan Nasruddin
doaj   +1 more source

Updates on Properties of Hamming Distance of Binary Fuzzy Codes over Fuzzy Vector Spaces and Their Application in Decoding Process

Fuzzy Information and Engineering, 2023
In this paper, we used the definition of fuzzy vector spaces and fuzzy subsets in combination in order to define fuzzy codes over a fuzzy vector space.
Mezgebu Manmekto Gereme, Jejaw Demamu, Berhanu Assaye Alaba   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Infinite dimensional linear groups with a spacious family of $G$-invariant subspaces [PDF]

Математичні Студії, 2013
Let $F$ be a field, $A$ be a vector space over $F$, $GL (F, A)$ be the group of all automorphisms of the vector space $A$. If $B leq A$ then denote by $mathop{m Core}_G (B)$ the largest $G$-invariant subspace of~$B$.
A. V. Sadovnichenko
doaj  

Comparative analysis of switching losses and current ripple of continuous and discontinuous SVPWM strategies for unbalanced two‐phase four‐leg VSI Fed unsymmetrical two‐phase induction motor

IET Power Electronics, 2021
This paper presents a comparative analysis of the continuous space vector pulse width modulation and the discontinuous space vector pulse width modulation in terms of the switching losses and current ripple reduction for the unbalanced two‐phase four‐leg
Kaset Muangthong, Chakrapong Charumit
doaj   +1 more source

Mirroring Vector Space Embedding for New Words

IEEE Access, 2021
Most embedding models used in natural language processing require retraining of the entire model to obtain the embedding value of a new word. In the current system, as retraining is repeated, the amount of data used for learning gradually increases.
Jihye Kim, Ok-Ran Jeong
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source